MAGE-A1, -A2, -A3, -A4, -A6, -A10, and -A12 are expressed in a significant proportion of primary and metastatic tumors of various histological types and are targets of tumor Ag-specific CTL. Individual MAGE-A expression varies from one tumor type to the other but, overall, the large majority of tumors expresses at least one MAGE-A Ag. Therefore, targeting epitopes shared by all MAGE-A Ags would...

A disintegrin and metalloproteinase 17 (ADAM17) regulates key cellular processes including proliferation and migration through the shedding of a diverse array of substrates such as epidermal growth factor receptor (EGFR) ligands. ADAM17 is implicated in the pathogenesis of many diseases including rheumatoid arthritis and cancers such as head and neck squamous cell carcinoma (HNSCC). As a centra...

We have previously shown that the leader proteinase (L(pro)) of foot-and-mouth disease virus (FMDV) blocks cap-dependent mRNA translation and that a genetically engineered FMDV lacking the leader proteinase coding region (A12-LLV2) is attenuated in cell culture and susceptible animals. The attenuated phenotype apparently is a consequence of the inability of A12-LLV2 to block the expression of t...

We study the minimal normal completion problem: given A ∈ Cn×n, how do we find an (n+q)×(n+q) normal matrix Aext := ( A A12 A21 A22 ) of smallest possible size? We will show that this smallest number q of rows and columns we need to add, called the normal defect of A, satisfies nd(A) ≥ max{i−(AA∗ −A∗A), i+(AA∗ −A∗A)}, where i±(M) denotes the number of positive and negative eigenvalues of the He...

ABCA12: adenosine triphosphate binding cassette A12 HI: harlequin ichthyosis NICU: neonatal intensive care unit INTRODUCTION Harlequin ichthyosis (HI) is a rare autosomal recessive congenital ichthyosis associated with mutations in the keratinocyte lipid transporter adenosine triphosphate binding cassette A12 (ABCA12), leading to disruption in lipid and protease transport into lamellar granules...

Abstract BACKGROUND We recently reported favorable safety, promising clinical efficacy and immunohistochemical indicators of response after radiotherapy (RT) plus escalating doses the CXCL12-neutralizing RNA-Spiegelmer olaptesed pegol (NOX-A12) for glioblastoma in German multicenter phase 1/2 GLORIA trial (NCT04121455). Here, we report outcomes RT dual inhibition vasculogenesis angiogenesis (be...

Marine oil spill detection is vital for strengthening the emergency commands of accidents and repairing marine environment after a disaster. Polarimetric Synthetic Aperture Radar (Pol-SAR) can obtain abundant information targets by measuring their complex scattering matrices, which conducive to analyze interpret mechanism slicks, look-alikes, seawater realize extraction slicks. The polarimetric...