BACKGROUND Surrogate endpoint biomarkers (SEBs) are used as intermediate indicators of a reduction in cancer incidence in chemoprevention studies. SEBs should be expressed differentially in normal and high risk tissue; appear at a well defined stage of carcinogenesis; be studied with reasonable sensitivity, specificity, and accuracy; and be modulated in chemoprevention trials. The concept of SE...

Toughening of polyamide 6 (PA6)/ Nanoclay (NC) nanocomposites with styrene-ethylene/butadiene-styrene copolymer (SEBS) using maleated styrene-ethylene/butadiene-styrene copolymer (mSEBS)/ as a compatibilizer were investigated by blending them in a co-rotating twin-screw extruder. Response surface method of experimental design was used for optimizing the material and processing parameters. Effec...

We assessed North Pacific right whale (Eubalaena japonica) seasonal and daily calling patterns in the southeastern Bering Sea (SEBS) using long-term hydrophone recordings from October 2000 through January 2006. We detected right whale calls on the SEBS middle shelf (<100 m depth) as early as May, intermittently throughout summer and fall, and as late as December. Calls also were detected on one...

Evapotranspiration is a major loss flux of the water balance in arid and semi-arid areas. The estimation of actual evapotranspiration has significance for hydrological and environmental purposes. The Surface Energy Balance System (SEBS) algorithm was applied to estimate actual evapotranspiration in the Qaidam Basin and its eight hydrological sub-regions, Northwest China. There were 3,036 cloud-...

The Canadian Society for Pharmaceutical Sciences organized a workshop on the current state of sciences of subsequent entry biologics (SEBs, biosimilars) on December 10th 2014 in the Health Canada location in Ottawa, ON. The day-long workshop provided an opportunity to discuss recent regulatory developments and a wide range of scientific issues related to SEBs. Following a discussion on the diff...