More than 18 million seabirds nest on 58 Pacific islands protected within vast U.S. Marine National Monuments (1.9 million km2). However, most of these seabird colonies are on low-elevation islands and sea-level rise (SLR) and accompanying high-water perturbations are predicted to escalate with climate change. To understand how SLR may impact protected islands and insular biodiversity, we model...

The inundation impact of sea level rise (SLR) is critical, since coastal regions of Europe house important critical infrastructures and large population centers. According to International Panel on Climate Change (IPCC) studies, the analysis of the SLR problem is complicated. Beyond the reported complexities involved in the analysis of this phenomenon, the expected spatial variability of SLR in...

The instrumentation provides basic tools for creating SLR timing systems operating at repetition rate up to a few KHz. There is a test setup to simulate the process of ranging to various satellites and to evaluate capabilities of this instrumentation for the KHz system design. The simulation of the CHAMP laser ranging at 2 KHz repetition rate is considered as an example. Test results show that ...

Various gene signatures of chemosensitivity in breast cancer have been discovered. One previous study employed t-test to find a signature of 31 probe sets (27 genes) from a group of patients who received weekly preoperative chemotherapy. Based on this signature, a 30-probe set diagonal linear discriminant analysis (DLDA-30) classifier of pathologic complete response (pCR) was constructed. In th...

In rodents, soluble leptin receptor (SLR) may be generated by alternative splicing of ObR mRNA and/or as a cleavage product of ObR membrane-anchored receptors. In this study, we investigated the contribution of both processes on the generation of SLR in 3-, 8-, and 24-month-old Wistar rats fed ad libitum (AL) or under food restriction (FR). To this end, we determined serum SLR levels and analyz...

Terminally misfolded proteins are selectively recognized and cleared by the endoplasmic reticulum-associated degradation (ERAD) pathway. SEL1L, a component of the ERAD machinery, plays an important role in selecting and transporting ERAD substrates for degradation. We have determined the crystal structure of the mouse SEL1L central domain comprising five Sel1-Like Repeats (SLR motifs 5 to 9; he...

Streptococcus pyogenes is an important human pathogen and surface structures allow it to adhere to, colonize and invade the human host. Proteins containing leucine rich repeats (LRR) have been identified in mammals, viruses, archaea and several bacterial species. The LRRs are often involved in protein-protein interaction, are typically 20-30 amino acids long and the defining feature of the LRR ...

BACKGROUND Normal displacement of the conus medullaris with unilateral and bilateral SLR has been quantified and the "principle of linear dependence" has been described. PURPOSE Explore whether previously recorded movements of conus medullaris with SLRs are i) primarily due to transmission of tensile forces transmitted through the neural tissues during SLR or ii) the result of reciprocal move...