Modulins represent microbial products that stimulate cytokine production in host cells. The modulins responsible for gram-positive sepsis remain poorly understood. Staphylococci release a factor (or factors) that activates nuclear factor-kappa B and stimulates cytokine production in cells of macrophage lineage. This factor, termed phenol-soluble modulin (PSM), has been recently isolated from cu...

Recently, the cDNA encoding a novel candidate for prostate cancer-specific antigen, named prostate-specific membrane antigen (PSM), was cloned from the LNCaP prostate cancer cell line (R. S. Israeli, C. T. Powell, W. R. Fair, and W. D. W. Heston, Cancer Res., 53: 227-230,1993). More recently, they also identified an alternatively spliced variant of PSM in normal prostate tissues (S. L. Su, I-P....

For canonical lipid raft mixtures of cholesterol (chol), N-palmitoylsphingomyelin (PSM), and 1-palmitoyl-2-oleoylphosphatidylcholine (POPC), electron paramagnetic resonance (EPR) of spin-labeled phospholipids--which is insensitive to domain size--is used to determine the ternary phase diagram at 23°C. No phase boundaries are found for binary POPC/chol mixtures, nor for ternary mixtures with PSM...

As energy availability limits usage time for mobile devices, modern wireless systems implement Power Saving Mechanisms (PSMs). Determining optimal PSM parameters and switch points when applying all PSM mechanisms jointly in the same scenario is a trade-off between power savings and system performance degradation. This work presents an unpublished performance study of the joint operation of Slee...

The F region downstream of the mecI gene in the SCCmec element in hospital-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) contains two bidirectionally overlapping open reading frames (ORFs), the fudoh ORF and the psm-mec ORF. The psm-mec ORF encodes a cytolysin, phenol-soluble modulin (PSM)-mec. Transformation of the F region into the Newman strain, which is a methicillin-sens...

INTRODUCTION We analyzed the trends of positive surgical margin (PSM) location in patients who had pT3 disease at robot-assisted radical prostatectomy (RARP). We aimed to describe our changing incidence of PSMs in the largest series to date of patients with pT3 disease who were treated by RARP. METHODS A single-institution, single-surgeon review was performed of all patients who underwent RAR...

Political stock markets (PSM) are sometimes seen as substitutes for opinion polls. On the bases of a behavioral model, specific preconditions were drawn out under which manipulation in PSM can weaken this argument. Evidence for manipulation is reported from the data of two separate PSM during the Berlin 99 state elections. JEL Classification: C93, D4, G1

Another component in Pattern-Oriented and ModelDriven Architecture (POMA) [1] is the concept of model transformation. The transformation of models is the process of creating a model from another model using transformation rules. In this paper, we present the transformation rules that enable to transform the five PIM models between them and also the five PSM models. These different PIM and PSM m...

This study presents a systematic methodology for MDA transformation that includes creating a platform independent model (PIM), transforming PIM into platform specific model (PSM), and transforming PSM into a Code model. The PIM is created first based on the use case, activity diagram and robustness diagram. The PIM is then transformed into a PSM based on three target platforms: Web-based user i...

Accurate staging is an important issue in managing patients with prostate cancer. Current staging modalities are poor predictors for locally advanced disease. In the present study, we investigated the role of a peripheral blood-based, nested reverse transcription-PCR (RT-PCR) for prostate-specific antigen (PSA) and prostate-specific membrane antigen (PSM) in prostate cancer staging. Our nested ...