نتایج جستجو برای: رویکرد in silico
تعداد نتایج: 17020617 فیلتر نتایج به سال:
background: eukaryotic proteins generally have signal peptides, which are not only crucial for their secretion efficiencies but are important for their expression levels. the coagulation factor ix (fix) is a glycoprotein that plays a fundamental role in a blood coagulation pathway. reduced levels or dysfunctional fix are associated with hemophilia b. to improve the hfix secretion efficiency in ...
Introduction: Acinetobacter baumannii is associated with hospital-acquired infections. Outer membrane protein A of A.baumannii (AbOmpA) is a well-characterized virulence factor which has important roles in pathogenesis of this bacterium. Methods: Based on our PCR-sequencing of ompA gene in the clinical isolates, AbOmpA protein can be categorized into two types, named here type-1 and type-2. We ...
Background and purpose: Interferon beta-1b recombinant protein is used for reducing the relapse rate and treatment in patients with Multiple sclerosis (MS). In this study, phylogenetic and in silico analysis of interferon beta-1b were conducted by servers and bioinformatics tools to predict its structural potential. Materials and methods: Physiological and physico-chemical characteristics of...
An increasing number of studies have demonstrated the effectiveness of flagellin (FliC) as an adjuvant. In this study, FliC(s) from Salmonella enterica serovar Typhimurium, Pseudomonas aeruginosa, and Escherichia coli were compared. In silico studies were designed to determine physicochemical parameters of FliC from different bacteria. The fliC gene corresponding to best model was amplified, cl...
objective: druggability of a target protein depends on the interacting micro-environment between the target protein and drugs. therefore, a precise knowledge of the interacting micro-environment between the target protein and drugs is requisite for drug discovery process. to understand such micro-environment, we performed in silico interaction analysis between a human target protein, dipeptidyl...
هدف: همان‌گونه که مشهود است، در سازمان‌های خدماتی به‌منظور برندسازی نیاز است ارزش‌های برندشان فعال و نهادینه شود؛ با این پیش‌فرض، پژوهش پیش‌رو هدف استخراج مدل فعال‌سازی برند داخلی از منظر فعالیت‌های مدیریت منابع انسانی تعریف اجرا شده است.طراحی/ روش‌شناسی/ رویکرد: روش مطالعۀ موردی رویکرد کیفی بانک ملت برای توسعۀ پیش گرفته شد. دو مرحلۀ اصلی طراحی گردید مصاحبه‌های عمیق فردی ۱۹ مدیر کارشناس مربوطه ...
Risk assessment of a transgene is one of the key steps in genetic transformation. Hence, in order to use cryIAc gene for production of transgenic plants, a library and in-silico research was performed to confirm safety of the gene for human comsumption, animal feed and environment. In the first step, the molecular mechanism of action of the CryIAc protein and its specific receptors in the midgu...
The properties relevant to pharmacokinetics and pharmacodynamics of four series of synthesized s-triazine derivatives have been studied by Quantitative structure-retention relationship (QSRR) approach. The chromatographic behavior of these compounds was investigated by using reversed-phase high performance thin-layer chromatography (RP-HPTLC). Chromatographic retention (RM0) was correlated with...
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