BACKGROUND Epidural analgesia (EDA) is used widely for postoperative pain treatment. However, studies have reported a failure rate of EDA of up to 30%. We aimed to evaluate the quality of postoperative EDA in patients undergoing a laparotomy in five Norwegian hospitals. METHODS This was a multicenter observational study in patients undergoing a laparotomy with epidural-based postoperative ana...

OBJECTIVE Thoracic aortic aneurysm is a common complication in patients with bicuspid aortic valve (BAV). Alternatively spliced extra domain A (EDA) of fibronectin (FN) has an essential role in tissue repair. Here we analyze the expression of FN spliceforms in dilated and nondilated ascending aorta of tricuspid aortic valve (TAV) and BAV patients. METHODS AND RESULTS The mRNA expression was a...

PURPOSE The purpose of this study was to assess the improved absorption and in vivo kinetic characteristics of a novel water-in-oil nanoemulsion containing evodiamine-phospholipid nanocomplex (NEEPN) when administered orally. METHODS NEEPN was fabricated by loading an evodiamine-phospholipid nanocomplex into a water-in-oil nanoemulsive system. The gastrointestinal absorption of NEEPN was inve...

in this case report we will describe a rare association between anhyrotic ectodermal dysplasia (aed) and immunodeficiency and autoimmunity [in our case: idiopathic thrombocytopenic purpura (itp) and crohn disease]. aed is a rare congenital disorder characterized by sparse hair, abnormal teeth and anhidrosis due to lack of eccrine glands. the survey of 87 cases with (aed) revealed only one irrit...

Loss aversion is a defining characteristic of prospect theory, whereby responses are stronger to losses than to equivalently sized gains (Kahneman & Tversky Econometrica, 47, 263-291, 1979). By monitoring electrodermal activity (EDA) during a gambling task, in this study we examined physiological activity during risky decisions, as well as to both obtained (e.g., gains and losses) and counterfa...

To study the changes on the electrical characteristics of the skin several problems have to be solved. We present a model for the electrodermal activity (EDA) that provides the means to detect and quantify four event types: a discrete event; a pair of events overlapping in the increasing zone; a pair of events overlapping in a decreasing zone; and an isolated small event. The presented EDA mode...

OBJECTIVE Many psychophysiological studies investigate whether psychopaths present low levels of electrodermal activity (EDA). However, despite evidence that varying degrees of psychopathy are normally distributed in the population, there is a paucity of EDA studies evaluating dimensionally. Moreover, although lack of empathy is a cornerstone of psychopathy, there has been a lack of studies usi...

The electrodermal activity (EDA) is a reliable physiological signal for monitoring the sympathetic nervous system. Several studies have demonstrated that EDA can be a source of effective markers for the assessment of emotional states in humans. There are two main methods for measuring EDA: endosomatic (internal electrical source) and exosomatic (external electrical source). Even though the exos...

BACKGROUND Patients with chronic obstructive pulmonary disease (COPD) have increased postoperative morbidity and mortality. Epidural analgesia (EDA) improves postoperative outcome but may worsen postoperative lung function. It is unknown whether patients with COPD benefit from EDA. The objective of this study was to determine whether patients with COPD undergoing major abdominal surgery benefit...

The purpose of this study was to test two 8-year-old identical twins with ectodermal dysplasia (ED) and their unaffected parents for the presence of mutations in the EDA gene with the hypothesis that they might be carrying a de novo mutation in EDA and potentially eligible for recombinant EDA therapy. DNA was extracted using saliva samples obtained from the identical twin girls and both parents...