We report five South African families of northern European descent (pedigrees 161, 162, 163, 164, and 166) in whom Romano-Ward long QT syndrome (LQT) segregates. The disease mapped to a group of linked markers on chromosome 11p15.5, with maximum combined two point lod scores, all generated at theta = 0, of 15.43 for the D11S922, 10.51 for the D11S1318, and 14.29 for the tyrosine hydroxylase (TH...

Type 2 congenital long QT syndrome (LQT-2) is linked to mutations in the human ether a-go-go-related gene (HERG) and is characterized by rate-corrected QT interval (QTc) prolongation, ventricular arrhythmias, syncope, and sudden death. Recognized triggers of these cardiac events include emotional and acoustic stimuli. Here we investigated the repeated occurrence of fever-induced polymorphic ven...

Early afterdepolarizations (EADs), thought to be highly arrhythmogenic in the case of long QT (LQT) syndromes, are most readily observed at slow heart rates and suppressed by fast heart rates. However, EADs are thought to contribute to tachycardia-dependent arrhythmias such as Torsades des pointes and ventricular fibrillation, leading to sudden cardiac death. Recent studies of simulated LQT in ...

To identify genes involved in cardiac arrhythmia, we investigated patients with long QT syndrome (LQT), an inherited disorder causing sudden death from a ventricular tachyarrythmia, torsade de pointes. We previously mapped LQT loci on chromosomes 11 (LQT1), 7 (LQT2), and 3 (LQT3). Here, linkage and physical mapping place LQT2 and a putative potassium channel gene, HERG, on chromosome 7q35-36. S...

یکی از عوامل محرک برای ایجاد جریان محوری درون روتور سانتریفیوژ به منظور افزایش عملکرد جداسازی، اسکوپ است. با توجه قرار گرفتن در معرض گاز ماخ بالا، دچار شوک شده و گرادیان‌های شدیدی اتفاق خواهد افتاد. این پژوهش اطراف حالت دوبعدی (r-θ) روش شبیه­سازی مستقیم مونت‌کارلو (DSMC) استفاده حل­گر dsmcFoam فواصل مختلف دیواره شبیه‌سازی نتایج نشان می‌دهد که فاصله کاهش زاویه برخورد اسکوپ، سبب بیشینه دما نیروی ...