Evidence links aryl hydrocarbon receptor (AHR) activation to rheumatoid arthritis (RA) pathogenesis, although results are inconsistent. AHR agonists inhibit pro-inflammatory cytokine expression in macrophages, pivotal cells in RA aetiopathogenesis, which hints at specific circuits that regulate the AHR pathway in RA macrophages. We compared microRNA (miR) expression in CD14(+) cells from patien...

Atherosclerosis and its complications rank as the leading cause of death with the hallmarks of lipid deposition and inflammatory response. MicroRNAs (miRNAs) have recently garnered increasing interests in cardiovascular disease. In this study, we investigated the function of miR-223 and the underlying mechanism in atherosclerosis. In the atherosclerotic ApoE-/- mice models, an obvious increase ...

microRNAs (miRNAs) have been hypothesized to function as oncogenes or tumor suppressors by targeting specific cancer-related genes. Previous studies have reported that miR-223 may serve as a tumor suppressor in a number of cancer types, however, knowledge of its targets in non-small cell lung cancer (NSCLC) remains limited. In the current study, miR-223 was found to inhibit cell proliferation i...

The scaling function S(q/­) is constrained by the physics of the highand low-frequency limits. As q=­ ! `, S must approach i­/q in order for j to assume its superconducting form, equation (1). At low frequencies, S approaches a real constant S1(0) which characterizes the d.c. conductivity of the normal state. By comparing the measured complex conductivity to equation (2), we can extract both th...

Tall fescue (Festuca arundinacea Schreb.) is an important forage resource for beef (Bos taurus L.) production in the North–South transition zone. Recently, the cultivar ‘Jesup’ was released to provide improved stand survival when infected with a novel (nontoxic) endophyte marketed as MaxQ (Pennington Seed, Madison, GA), and warrants evaluation as a source of winter hay for beef cattle. Intake a...

Therapeutic hypothermia (TH) may induce pharmacokinetic changes that may affect the level of sedation. We have compared the disposition of morphine, midazolam, fentanyl, and propofol in TH with normothermia in man. Fourteen patients treated with TH following cardiac arrest (33–34°C) were compared with eight matched critically ill patients (36–38°C). Continuous infusions of morphine and midazola...

Morphological and immunocytochemical studies have elucidated the complex processes involved in atherogenesis. The notion of plaque instability has emerged from this work and underscored the importance of inflammation in determining clinical complications associated with atherosclerosis, such as acute coronary syndrome. Cells of the immune system have been detected within atherosclerotic lesions...

PURPOSE Recent microarray and RNA-sequencing studies have uncovered aberrantly expressed microRNAs (miRNA) in Barrett's esophagus-associated esophageal adenocarcinoma. The functional significance of these miRNAs in esophageal adenocarcinoma initiation and progression is largely unknown. EXPERIMENTAL DESIGN Expression levels of miR-199a/b-3p, -199a-5p, -199b-5p, -200b, -200c, -223, and -375 we...

The structure of β-molybdenum dichloride is compared with that of TcCl(2) using EXAFS spectroscopy. For TcCl(2), the Tc atom is surrounded by Tc atoms at 2.13(2), 3.45(3), 3.79(4), and 4.02(4) Å. For β-MoCl(2), the Mo is surrounded by Mo atoms at 2.21(2), 2.91(3), and 3.83(4) Å. The latter distances are consistent with the presence of an [Mo(4)Cl(12)] unit in the solid state, one constituted b...