Somatostatin (SOM) is a widely distributed peptide in the central nervous system and exerts a variety of hormonal and neural actions. Although SOM is assumed to play an important role in spinal nociceptive processing, its exact function remains unclear. In fact, earlier pharmacological studies have provided results that support either a facilitatory or inhibitory role for SOM in nociception. In...

In this paper, two generalizations of the SOM are introduced. The first of these extends the SOM to deal with more generalized classes of objects besides the vector dataset. This generalization is realized by employing modular networks instead of reference vector units and is thus called a modular network SOM (mnSOM). The second generalization involves the extension of the SOM from ‘map’ to ‘ho...

This chapter provides an overview on the self-organised map (SOM) in the context of manifold mapping. It first reviews the background of the SOM and issues on its cost function and topology measures. Then its variant, the visualisation induced SOM (ViSOM) proposed for preserving local metric on the map, is introduced and reviewed for data visualisation. The relationships among the SOM, ViSOM, m...

I denna avhandling studeras prostatacancerns naturalförlopp och värdet av befi ntliga prognostiska faktorer. Man studerar också några nya tänkbara prognostiska faktorer. Dessutom tittar man på tids trender för prostata tumörer som är upptäckta incidentalt vid två olika typer av operationer, som görs vid vattenkastningsbesvär. Avhandlingen bygger på två unika prostata cancer material som samlats...

Small-diameter sensory neurones found in the rat dorsal root ganglia (DRG) include cells sensitive to glial cell line-derived neurotrophic factor (GDNF), which express the inhibitory peptide somatostatin (SOM). Here we addressed the functional relationship between GDNF and sensory neurone-derived SOM. Topical application of GDNF through the rat isolated dorsal horn of the spinal cord promoted a...

Gonkowski S. & Całka J. 2012. The influence of selected pathological states on the somatostatin-like immunoreactive (SOM-LI) endocrine cells in the mucosal layer of the porcine descending colon. Pesquisa Veterinária Brasileiia 32(Supl.1):79-83. Division of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowski Str. 13, Olsztyn, 10-957, Poland. E-mail: s...

We propose a new method called C-SOM for function approximation. C-SOM extends the standard Self-Organizing Map (SOM) with a combination of Local Linear Mapping (LLM) and cubic spline based interpolation techniques to improve standard SOMs' generalization capabilities. CSOM uses the gradient information provided by the LLM technique to compute a cubic spline interpolation in the input space bet...