Ulcerative colitis (UC) is a chronic disease characterized by diffuse inflammation of the intestinal mucosa of the large bowel. Omega-3 (ω3) fatty acid supplementation has been associated with a decreased production of inflammatory cytokines involved in UC pathogenesis. The aim of this study was to determine the preventive and therapeutic potential of eicosapentaenoic acid monoglyceride (MAG-EP...

Anti-myelin-associated-glycoprotein (MAG) neuropathy is an intractable autoimmune polyneuropathy. The antigenic region of MAG is the human natural killer-1 (HNK-1) carbohydrate. We and others previously suggested that the extension of antibody reactivities to HNK-1-bearing proteins other than MAG was associated with treatment resistance, without statistical analyses. In this study, we establish...

Mercaptoacetyltriglycine forms complexes with (186/188)Re and (99m)Tc radionuclides that are useful in nuclear medicine because they are substrates of the renal anion transport system. However, the renal clearance of [MO(MAG(3))](2-)(MAG(3) = penta-anionic form of mercaptoacetyltriglycine, M = Re, Tc) complexes are less than ideal. Organic sulphonates are also transported by the renal anion tra...

We report deep near-infrared and optical observations of the X-ray point source in the Cassiopeia A supernova remnant, CXO J232327.9+584842. We have identified a J = 21.4 ± 0.3 mag and K s = 20.5 ± 0.3 mag source within the 1-σ error circle, but we believe this source is a foreground Pop II star with T eff = 2600–2800 K at a distance of ≈ 2 kpc, which could not be the X-ray point source. We do ...

The myelin-associated glycoprotein (MAG) has been shown to be inhibitory for certain neurons in vitro (Mukhopadhyay et al., 1994; McKerracher et al., 1994). To investigate whether MAG is an inhibitory component in peripheral myelin in vivo, MAG-deficient mutant mice were cross-bred with C57BL/Wlds mice that have delayed lesion-induced myelin degeneration and axon regrowth. While in crushed nerv...

Nerve cells depend on specific interactions with glial cells for proper function. Myelinating glial cells are thought to associate with neuronal axons, in part, via the cell-surface adhesion protein, myelin-associated glycoprotein (MAG). MAG is also thought to be a major inhibitor of neurite outgrowth (axon regeneration) in the adult central nervous system. Primary structure and in vitro functi...

MAG is a potent inhibitor of axonal regeneration. Here, inhibition by MAG, and myelin in general, is blocked if neurons are exposed to neurotrophins before encountering the inhibitor; priming cerebellar neurons with BDNF or GDNF, but not NGF, or priming DRG neurons with any of these neurotrophins blocks inhibition by MAG/myelin. Dibutyryl cAMP also overcomes inhibition by MAG/myelin, and cAMP i...

Central to the HIV testing discourse are considerations of legal, constitutional, and human rights. In South Africa, everyone has the constitutionally guaranteed right to dignity (Constitution, Section 10), the right to privacy (Constitution, Section 14), and the right to autonomy and bodily integrity (Constitution, Section 12). Section 12(2)(c) of the Bill of Rights, protects everyone against ...

Myelin-associated glycoprotein (MAG) is a myelin-expressed cell-adhesion and bi-directional signalling molecule. MAG maintains the myelin-axon spacing by interacting with specific neuronal glycolipids (gangliosides), inhibits axon regeneration and controls myelin formation. The mechanisms underlying MAG adhesion and signalling are unresolved. We present crystal structures of the MAG full ectodo...

جوشکاری قوسی تنگستن – گاز یکی از فرایندهای مهم جوشکاری در صنعت می باشد که از الکترود غیر مصرفی تنگستن برای جوشکاری استفاده می کند. این روش برای جوشکاری قطعات نازک فولادهای ضد زنگ و فلزات غیر آهنی از قبیل آلومینیوم، منیزیم و آلیاژهای مس به کار برده می شود. در این تحقیق با طراحی و ساخت یک بازوی جوشکاری اتوماتیک که سرعت جوشکاری آن بوسیله میکرو کنترلر کنترل می شود در شرایط مختلف جوشکاری مانند انواع...