Disruption of ionic homeostasis and neuronal hyperexcitability contribute to early brain injury after subarachnoid hemorrhage (SAH). The hyperpolarization-activated/cyclic nucleotide (HCN)-gated channels play critical role in the regulation of neuronal excitability in hippocampus CA1 region and neocortex, in which the abnormal neuronal activities are more readily provoked. This study was to inv...

In this paper, we propose a novel interconnection network called three-level hierarchical cubic network (3-HCN), which extends the construction of hierarchical cubic networks (HCN) and ooers many additional advantages. The 3-HCN (with diameter links) has diameter smaller than that of an n-cube of the same size and uses nodes of degree 1 3 n + 2. We develop eecient and elegant algorithms for rou...

HCN is the putative product of C-1 and amino moieties of 1-aminocyclopropane-1-carboxylic acid (ACC) during its conversion to ethylene. In apple (Malus sylvestrus Mill.) slices or auxin-treated mungbean (Vigna radiata L.) hypocotyls, which produced ethylene at high rates, the steady state concentration of HCN was found to be no higher than 0.2 micromolar, which was too low to inhibit respiratio...

Aims. Our goal is to study molecular gas properties in nuclei and large scale outflows/winds from active galactic nuclei (AGNs) and starburst galaxies. Methods. We obtained high resolution (0. ′′25 to 0. ′′90) observations of HCN and HCO J = 3 → 2 of the ultraluminous QSO galaxy Mrk 231 with the IRAM Plateau de Bure Interferometer (PdBI). Results. We find luminous HCN and HCO J = 3 → 2 emission...

BACKGROUND The pacemaker current I(f) is present in atrial and ventricular myocytes. However, it remains controversial whether I(f) overexpression in diseased states might play a role for arrhythmogenesis, because first I(f) activation in whole-cell recordings hardly overlapped the diastolic voltage of working myocardium. METHODS AND RESULTS To obtain further insight into I(HCN) and I(f) prop...

HCN J =8→ 7 sub-millimetre line emission produced in the circumstellar envelope around the extreme carbon star IRC+10216 has been imaged at sub-arcsecond angular resolution using the SMA. Supplemented by a detailed excitation analysis the average fractional abundance of HCN in the inner wind (. 5× 10 cm) is estimated to be about 4× 10, translating into a total HCN fractional abundance of 2× 10 ...

Context. The thermal structure of Titan’s thermosphere is determined by the balance between several heating and cooling processes. These processes must be accurately modeled to correctly interpret the available measurements and enhance our understanding of the formation and evolution of this atmosphere. One of the most important thermospheric cooling process for Titan is emission in the HCN rot...

Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic infections in individuals suffering from the genetic disorder cystic fibrosis. In P. aeruginosa, the transcriptional regulator AlgR controls a variety of virulence factors, including alginate production, twitching motility, biofilm formation, quorum sensing, and hydrogen cyanide (HCN) production. In this study, the regulati...

Hyperpolarization-activated, cyclic nucleotide-gated nonselective (HCN) channels modulate both membrane potential and resistance and play a significant role in synaptic plasticity. We compared the influence of HCN channels on long-term depression (LTD) at the medial perforant path-granule cell synapse in early postnatal (P9-15) and adult (P30-60) rats. LTD was elicited in P9-15 slices using low...

A study to assess the various gases emitted by motorcycles in a metropolitan State, Uyo, in Nigeria was carried out. Two hundred commercial motorcycles the mostly available means of transport were used for the study drawn from seven motorcycle parks. The gases examined were nitrogen dioxide, sulphur dioxide, carbon monoxide, chlorine, hydrogen sulphide and ammonia. The overall collection result...