microRNAs (miRNAs/miRs) may have a crucial function in tumor metastasis through the regulation of a plethora of signaling pathways. Increasing evidence has shown that miR-199a is important in regulating the tumor metastasis of ovarian cancer, although the precise biological function of miR-199a is unclear at present. In the current study, it was observed that the expression levels of miR-199a w...

To probe the effect of the protein environment on the retinal chromophore of rhodopsin, we have performed molecular dynamics simulations using combined quantum mechanics / molecular mechanics (QM/MM). The starting geometry of the protein is based on the 2.6Å X-ray structure of bovine rhodopsin by Okada et al. The wild type chromophore of rhodopsin shows a highly twisted conformation around the ...

| Ensembles of multi-layer network is set up to predict the carbon-13 nuclear magnetic resonance (C13 NMR) chemical shifts of a series of mono-substituted benzenes. The descriptors (inputs) used are twelve structural-based vectors that correspond to the calculated H uckel and Gasteiger electron densities of the mono-substituted aromatic systems and four graphical descriptors that correspond to ...

We have examined whether active immunization with c13 protein, a hybrid protein of the first 81 amino acids of the viral NS1 nonstructural protein and the HA2 subunit of A/PR/8 (H1N1) hemagglutinin, could protect BALB/c mice from challenge with A/PR/8 H1 subtype virus. Mice immunized with the c13 protein had a significant reduction of pulmonary virus titers with A/PR/8 (H1) virus, but failed to...

El ácido elágico (AELG) es un metabolito en varias plantas y vegetales medicinales se puede encontrar libre o como parte de la molécula más compleja (elagitaninos). Esta investigación tuvo objetivo estudiar las interacciones AELG los aminoácidos (AA) tejidos humanos. software Hyperchem utilizó base para química cuántica. Se tomó teoría del coeficiente transferencia electrones (CTE). Los resulta...