We describe a method termed MADM (mosaic analysis with double markers) in mice that allows simultaneous labeling and gene knockout in clones of somatic cells or isolated single cells in vivo. Two reciprocally chimeric genes, each containing the N terminus of one marker and the C terminus of the other marker interrupted by a loxP-containing intron, are knocked in at identical locations on homolo...

The choice of an aggregation function is a common problem in Multi Attribute Decision Making (MADM) systems. The Method of Imprecision (MoI) is a formal theory for the manipulation of preliminary design information that represents preferences among design alternatives with the mathematics of fuzzy sets. The MoI formulates the preliminary design problem as a MADM problem. To date, two aggregatio...

Stem cell competition has emerged as a mechanism for selecting fit stem cells/progenitors and controlling tumourigenesis. However, little is known about the underlying molecular mechanism. Here we identify Mlf1-adaptor molecule (Madm), a novel tumour suppressor that regulates the competition between germline stem cells (GSCs) and somatic cyst stem cells (CySCs) for niche occupancy. Madm knockdo...

Multi-attribute decision making (MADM) play an important role in many applications, due to the efficiency to handle indeterminate and inconsistent information, interval neutrosophic sets is widely used to model indeterminate information. In this paper, a new MADM method based on interval neutrosophic trapezoid linguistic weighted arithmetic averaging aggregation (INTrLWAA) operator and interval...

Abstract. This paper introduces the concept of intuitionistic fuzzy dominance matrix (IFDM) for solving multi attribute decision making (MADM) problems in intuitionistic fuzzy soft sets. during decision making problems, dominance of one expert over others play an important role to find out the optimal alternatives. We have proposed an algorithm approach to solve MADM problems using IFDM. Finall...

Multi-attribute decision making (MADM). Play an important role in many applications, due to the efficiency to handle indeterminate and inconsistent information, single valued neutrosophic sets is widely used to model indeterminate information. In this paper, a new MADM method based on neutrosophic trapezoid linguistic weighted arithmetic averaging aggregation SVNTrLWAA operator and neutrosophic...

In this paper, we investigate the multiple attribute decision making (MADM) problemsfor evaluating the archives websites’ performance with interval intuitionistic fuzzy information.Then,based on the TOPSIS method, calculation steps for solving MADM problems for evaluating thearchives websites’ performance with interval intuitionistic fuzzy information are given. The weightedHamming distances pr...