BACKGROUND Screening for syphilis with treponemal chemiluminescence immunoassays (CIA) identifies patients with discordant serology who are not identified with traditional screening methods (eg, CIA-positive, rapid plasma regain (RPR)-negative). We sought to describe the clinical characteristics and management of patients with discordant syphilis serology. METHODS From August 2007-October 200...

INTRODUCTION Due to the existence of a variety of types of non-venereal syphilis caused by the related T. pallidum, regular serological testing such as Rapid Plasma Reagin (RPR) and Chemiluminescent Microparticle Immunoassay Technique (CMIA) are often unable to differentiate venereal syphilis from the non- venereal one, hence, the interest in the use of molecular biology testing for a confirmat...

BACKGROUND Elevated resting heart rate (RHR) or resting pulse rate (RPR) is associated with increased risk of hypertension development. However, information is limited to adults. The purpose of this study is to analyze this association among Chinese children in a prospective design. METHODS A total of 4861 children who participated in the Blood Pressure Surveillance Program (2011-2017) were s...

Background Automated analyzer-based nontreponemal serological tests for syphilis (STS) have been used for several decades. Objective In this study, we evaluated serological responses to treatment and proposed clinical guidelines for automated STS. Methods This retrospective cohort study analyzed human immunodeficiency virus-negative syphilis patients who were diagnosed with automated rapid ...

Sera from 536 adults and children in Swaziland were examined for their reactivity in the rapid plasma reagin (RPR) and Treponema pallidum haemagglutination (TPHA) tests. None of 130 sera from children was reactive in either test; 8.6% of sera from 185 healthy adults were reactive in the RPR test and 33% in the TPHA test; 24.5% of 220 sera from patients with genital ulcers were RPR-positive and ...

The toluidine red unheated serum test (TRUST) antigen, a macroscopic flocculation test antigen developed by Pettit et al. (J. Clin. Microbiol. 18:1141-1145, 1983) by modifying the color-coded antigen of Kasatiya and Lambert (Appl. Microbiol. 28:317-318, 1974), was compared with the Venereal Disease Research Laboratory (VDRL) slide and rapid plasma reagin (RPR) 18-mm circle card tests for sensit...

An experiment was conducted to determine whether a commercial strain of turkey hens exhibits relative photorefractoriness (rPR) during a reproductive cycle and to ascertain whether plasma levels of certain hormones early in the reproductive cycle might be associated with subsequent expression of rPR or absolute photorefractoriness (aPR). Twenty-seven percent of hens maintained on a stimulatory ...

A 39-year-old woman presented with a 6-week history of an ulcerated and indurated lesion in the upper lip (Fig. 1). The histological study showed an ulcer with dense lymphoplasmacytic infiltrate and the immunohistochemistry (IHC) was positive for spirochetes. Both, the rapid plasma reagin test (RPR) and the microhemaglutination of the Treponema pallidum (MHA-TP) test were reactive with a RPR of...

Sexually transmitted diseases (STD’s), including Syphilis, are associated with an increased risk of Human immunodeficiency virus (HIV) infection. Though Rapid Plasma Reagin test (RPR) is a screening test to diagnose syphilis, a negative RPR may not rule out syphilis in HIV sero-reactive patients. For laboratory confirmation, one specific treponemal test, namely Treponema Pallidum Haemagglutinat...

BACKGROUND Patients with stable coronary artery disease on single-antiplatelet therapy with aspirin are still at risk for atherothrombotic events, and high on-aspirin residual platelet reactivity (RPR) has been suggested as a risk factor. METHODS AND RESULTS In this randomized trial, the association between platelet function determined by the PFA100 platelet function analyzer system (Siemens ...