Melatonin rhythms were assessed in 49 registered blind individuals by measurement of the urinary metabolite of melatonin, 6-sulfatoxymelatonin (aMT6s). Subjects had different causes of visual loss and were classified as having light perception or better (LP; n = 19) or having no perception of light (NPL; n = 30). Subjects collected four-hourly urine samples (eight-hourly overnight) for 48 h at ...

Photoparoxysmal response (PPR) is an abnormal visual sensitivity of the brain in reaction to intermittent photic stimulation. It is an epilepsy-related electroencephalographic trait with high prevalence in idiopathic epilepsies, especially in common idiopathic generalized epilepsies (IGEs), such as childhood absence epilepsy and juvenile myoclonic epilepsy. This degree of co-morbidity suggests ...

Even in this Internet age, reading code is quite hard. Existing Program Visualisation systems could not make visualisation of code in existing languages any easier because the semantics of the languages were not designed with code visualisation in mind. NPL is an experimental procedural language designed to aid program visualisation and is based on a paradigm called ”Connect Oriented Paradigm” ...

Over several years NPL has been developing a calibration service for electron beam radiotherapy. To test this service, a trial calibration of therapy level electron beam ionisation chambers was carried out in 1996, involving fourteen radiotherapy centres supplying a total of eighteen chambers and twelve electrometers. All chambers were either of the NACP 02 (Scanditronix) or Markus (PTW) type. ...

In complex disease studies, it is crucial to perform multipoint linkage analysis with many markers and to use robust nonparametric methods that take account of all pedigree information. Currently available methods fall short in both regards. In this paper, we describe how to extract complete multipoint inheritance information from general pedigrees of moderate size. This information is captured...

A research project in Machine Translation (MT) from Russian into English was started at the National Physical Laboratory in 1960 and carried on until its conclusion in 1966. Over these years the project evolved from a simple ‘improved word for word translation’ into a more advanced stage of translation of sentences and phrases with a certain amount of syntactical analysis, and included also idi...