We report a versatile method for improving post-bonding wafer alignment accuracy and BCB thickness uniformity in stacks bonded with soft-baked BCB. It is based on novel BCB-based micro-pillars that act as anchors during bonding. The anchor structures become natural part of the bonding interface therefore causing minimal interference to optical, electrical mechanical properties stack. studied th...

We present the heterogeneous integration of InP/InGaAsP photodetectors onto ultracompact Silicon-onInsulator (SOI) waveguide circuits using benzocyclobutene (BCB) die to wafer bonding. This technology development enables the integration of a photonic interconnection layer on top of CMOS. Fabrication processes were optimized and the transfer of a passive Silicon-on-Insulator waveguide layer usin...

Metabolomics focused on reproduction have been the subject of special interest in the past decade. Metabolite profiling provides detailed information on the status of follicular fluid and follicular cells which accompany the growing oocyte. Although nutrients present in the diet reach oocytes via the follicular fluid, it is not evident whether oocyte/embryo quality can be predicted based on the...

With an aim of ultra-low power operation, membranetype distributed-feedback (DFB) lasers consisting of wirelike active regions are realized with an InP-based high index-contrast waveguide by using benzocyclobutene (BCB) as well as direct boding on a silicon-on-insulator (SOI) substrate. Lateral current injection (LCI) type lasers on a semi-insulating (SI) InP substrate are also presented. Keywo...

A comprehensive in vivo evaluation of brain penetrability and central nervous system (CNS) pharmacokinetics of atomoxetine in rats was conducted using brain microdialysis. We sought to determine the nature and extent of transport at the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCB) and to characterize brain extracellular and cellular disposition. The steady-state extrace...

The developing history of polymer materials tells that the invention of novel polymers with excellent performance is generally originated from the synthesis of new polymerizable monomers. Among kinds of monomers, benzocyclobutene (BCB) has attracted much interest because of its unique molecular structure and polymer properties (1-2). The structure of BCB is shown as following with the numbering...

Shortest transitive edge relation presents an alternative to transitive closure relation for answering a class of complex biological queries that requires connectivity information but not the full transitive closure. A biological querie such “ find each downstream protein interacting with glutamine synthetase using five or fewer interactions ” does not require transitive closure. Shortest trans...

Maintaining brain Cu homeostasis is vital for normal brain function. The role of systemic Fe deficiency (FeD) or overload (FeO) due to metabolic diseases or environmental insults in Cu homeostasis in the cerebrospinal fluid (CSF) and brain tissues remains unknown. This study was designed to investigate how blood-brain barrier (BBB) and blood-SCF barrier (BCB) regulated Cu transport and how FeO ...

Lexical access difficulties are frequent in normal aging and initial stages of dementia.Verbal fluency tests are valuable to detect cognitive decline, evidencing lexico-semantic and executive dysfunction. Objectives To establish which language tests can contribute in detecting dementia and to verify schooling influence on subject performance. Method 74 subjects: 33 controls, 17 Clinical Dem...

Zinc (Zn) is an essential element for normal brain function; an abnormal Zn homeostasis in brain and the cerebrospinal fluid (CSF) has been implied in the etiology of Alzheimer’s disease (AD). However, the mechanisms that regulate Zn transport in the blood– brain interface remain unknown. This study was designed to investigate Zn transport by the blood–CSF barrier (BCB) in the choroid plexus, w...