Early cognitive impairment in Alzheimer's disease (AD) correlates with medial temporal lobe dysfunction, including two areas essential for memory formation: the entorhinal cortex and dentate gyrus (DG). In the Tg2576 animal model for AD amyloidosis, activation of the peroxisome proliferator-activated receptor-gamma (PPARγ) with rosiglitazone (RSG) ameliorates hippocampus-dependent cognitive imp...

Lipolysis is an important process determining fuel metabolism, and insulin regulates this process in adipose tissue. The aim of this study was to investigate the long-term effects of insulin, an insulin enhancer (rosiglitazone [RSG]), and insulin in combination with RSG on the regulation of lipolysis and lipogenesis in human abdominal subcutaneous fat. Lipolysis and lipogenesis were assessed by...

AIM To compare the efficacy, safety and tolerability of adding rosiglitazone (RSG) vs. sulphonylurea (SU) dose escalation in older type 2 diabetes mellitus (T2DM) patients inadequately controlled on SU therapy. METHODS A total of 227 T2DM patients from 48 centres in the USA and Canada, aged > or =60 years, were randomized to receive RSG (4 mg) or placebo once daily in combination with glipizi...

Background: Sleeve gastrectomy (SG) represents the fastest growing bariatric surgical procedure and has been associated with few long term complications. SG provides the opportunity to act as a bridge for future procedures in the super obese, improving comorbidities before laparoscopic Roux-en-Y gastric bypass (RYGB). With the technological advancement in minimally invasive surgery, many surgeo...

Context. Red super-giant (RSG) stars exhibit significant mass loss through a slow and dense wind. They are often considered to be the more massive counter-parts of Asymptotic Giant Branch (AGB) stars. While the AGB mass-loss is linked to their strong pulsations, the RSG are often only weakly variable. This raises the question whether their wind-driving mechanism and the dust composition in the ...

Regional Student Groups are groups established and managed by the ISCB-Student Council in different regions of the world. The article highlights some of the initiatives and management lessons from our 'top-performing' Spotlight Regional Student Groups (RSGs), RSG-Argentina and RSG-UK, for the current year (2016). In addition, it details some of the operational hurdles faced by RSGs and possible...

BACKGROUND The objective of this study was to investigate the effects of Rosiglitazone (RSG) infusion therapy following minimally invasive surgery (MIS) for intracerebral hemorrhage(ICH) evacuation on perihematomal secondary brain damage as assessed by MMP-9 levels, blood-brain barrier (BBB) permeability and neurological function. METHODS A total of 40 male rabbits (2.8-3.4 kg) was randomly a...

It is not clear how protein cargo is sorted to and retained in forming regulated secretory granules (RSG). Here, the sulfated mucin-type glycoprotein pro-Muclin was tested for its ability to induce RSG in the poorly differentiated rat pancreatic cell line AR42J. AR42J cells express RSG content proteins, but they fail to make granules. Adenovirus-pro-Muclin-infected AR42J cells store amylase, ac...

Rosiglitazone (RSG), developed for the treatment of type 2 diabetes mellitus, is known to have potent effects on carbohydrate and lipid metabolism leading to the improvement of insulin sensitivity in target tissues. To further assess the capacity of RSG to normalize gene expression in insulin-sensitive tissues, we compared groups of 18-day-treated db/db mice with increasing oral doses of RSG (1...

ABSTRACT We conduct three-dimensional hydrodynamical simulations of common envelope jets supernova (CEJSN) events where we assume that a neutron star (NS) launches as it orbits inside the outer zones red supergiant (RSG) envelope, and find negative jet feedback coefficient to be ≃ 0.1–0.2. This is factor by which reduce mass accretion rate on NS they remove from inflate bubbles (cocoons). Our r...