BACKGROUND The frequent need for blood transfusion in children with SCA creates the impression that IDA is rare in this class of children. OBJECTIVES The objective of the study is to determine the prevalence of IDA in a population of under-five children with SCA in Lagos, Nigeria. METHODOLOGY Serum iron, total iron binding capacity, transferrin saturation and serum ferritin were assayed in ...

BACKGROUND Iron deficiency Anemia (IDA) in children is a recognized public health problem that impacts adversely on child morbidity, mortality and impairs cognitive development. In Pakistan information on the true prevalence and predictors of IDA is limited. This study sought to investigate IDA in children under five years of age using data from a nationally representative stratified cross-sect...

PURPOSE A substantial proportion of patients with colorectal cancer (CRC) present with iron deficiency anemia (IDA), and fecal immunochemical test (FIT) has proven to be an effective method for detecting the majority of CRC cases. A combination strategy of FIT results and IDA may be useful for risk stratification for detecting advanced colorectal neoplasia (ACRN). We compared the prevalence of ...

UNLABELLED Reactive gliosis involving activation and proliferation of astrocytes and microglia, is a widespread but largely complex and graded glial response to brain injury. Astroglial population has a previously underestimated high heterogeneity with cells differing in their morphology, gene expression profile, and response to injury. Here, we identified a subset of reactive astrocytes isolat...

We present the following results about IDA* and related algorithms: We show that IDA* is not asymptotically optimal in all of the cases where it was thought to be so. In particular, there are trees satisfying all of the conditions previously thought to guarantee asymptotic optimality for IDA*, such that IDA* will expand more than O(N) nodes, where N is the number of nodes eligible for expansion...

Abscission is a developmental process that enables plants to shed unwanted organs. In Arabidopsis, the floral organ abscission is regulated by a signaling pathway consisting of the peptide ligand IDA, the receptor-like kinases (RLKs) HAE and HSL2, and a downstream MAP kinase (MAPK) cascade. However, little is known about the molecular link between ligand-receptor pairs and intracellular signali...

Inflammation can lead to malabsorption of important micronutrients such as iron. Malabsorption and nutritional deficiency can be caused by a variety of pathological and environmental factors causing a range of other symptoms commonly caused by both H. pylori infection and coeliac disease (CD). National guidelines suggest the routine taking of duodenal biopsies to exclude CD when investigating p...

Cristina Maria Areias, Benedita Sampaio-Maia, Hercilia Guimaraes, Paulo Melo, David Andrade I Odontopediatrics, Faculdade de Medicina Dentária da Universidade do Porto, Porto, PT. II Microbiology, Faculdade de Medicina Dentária da Universidade do Porto, Porto, PT. III Pediatrics, Faculdade de Medicina Universidade do Porto, Porto, PT. IV Dentistry, Faculdade de Medicina Dentária da Universidade...

Plants constantly renew during their life cycle and thus require to shed senescent and damaged organs. Floral abscission is controlled by the leucine-rich repeat receptor kinase (LRR-RK) HAESA and the peptide hormone IDA. It is unknown how expression of IDA in the abscission zone leads to HAESA activation. Here we show that IDA is sensed directly by the HAESA ectodomain. Crystal structures of H...