نتایج جستجو برای: بیماری amd

تعداد نتایج: 50532  

2013
Elizabeth G. Holliday Albert V. Smith Belinda K. Cornes Gabriëlle H. S. Buitendijk Richard A. Jensen Xueling Sim Thor Aspelund Tin Aung Paul N. Baird Eric Boerwinkle Ching Yu Cheng Cornelia M. van Duijn Gudny Eiriksdottir Vilmundur Gudnason Tamara Harris Alex W. Hewitt Michael Inouye Fridbert Jonasson Barbara E. K. Klein Lenore Launer Xiaohui Li Gerald Liew Thomas Lumley Patrick McElduff Barbara McKnight Paul Mitchell Bruce M. Psaty Elena Rochtchina Jerome I. Rotter Rodney J. Scott Wanting Tay Kent Taylor Yik Ying Teo André G. Uitterlinden Ananth Viswanathan Sophia Xie Johannes R. Vingerling Caroline C. W. Klaver E. Shyong Tai David Siscovick Ronald Klein Mary Frances Cotch Tien Y. Wong John Attia Jie Jin Wang

Genetic factors explain a majority of risk variance for age-related macular degeneration (AMD). While genome-wide association studies (GWAS) for late AMD implicate genes in complement, inflammatory and lipid pathways, the genetic architecture of early AMD has been relatively under studied. We conducted a GWAS meta-analysis of early AMD, including 4,089 individuals with prevalent signs of early ...

2016
Linna Lu Shiqiong Xu Fangling He Yan Liu Yidan Zhang Jing Wang Zhiliang Wang Xianqun Fan

Age-related macular degeneration (AMD) is a major cause of irreversible blindness. Choroidal structural changes seem to be inevitable in AMD pathogenesis. Our study revealed associated choroidal microstructural changes in AMD eyes.The aim of the study was to compare choroidal microstructural changes in eyes with AMD of different stages.The study was a retrospective, cross-sectional case series....

2009
DanHong Zhu Xuemei Deng Jing Xu David R Hinton

Age-related macular degeneration (AMD), the leading cause of blindness in the elderly, targets the retinal pigment epithelium (RPE), a monolayer of cells at the back of the eye. As AMD progresses, it can develop into two distinct forms of late AMD: "dry," atrophic AMD, characterized by RPE senescence and geographic RPE loss, and "wet," neovascular AMD, characterized by RPE activation with abnor...

2016
Nicole T. M. Saksens Yara T. E. Lechanteur Sanne K. Verbakel Joannes M. M. Groenewoud Mohamed R. Daha Tina Schick Sascha Fauser Camiel J. F. Boon Carel B. Hoyng Anneke I. den Hollander

AIMS Age-related macular degeneration (AMD) is a multifactorial disease, in which complement-mediated inflammation plays a pivotal role. A positive family history is an important risk factor for developing AMD. Certain lifestyle factors are shown to be significantly associated with AMD in non-familial cases, but not in familial cases. This study aimed to investigate whether the contribution of ...

2014
Mariko Sasaki Ryo Kawasaki Atsuro Uchida Takashi Koto Hajime Shinoda Kazuo Tsubota Tien Yin Wong Yoko Ozawa

PURPOSE To investigate the relationship between the early signs of age-related macular degeneration (AMD) and the risk of developing exudative AMD (typical AMD or polypoidal choroidal vasculopathy [PCV]) in the fellow eye of Japanese patients with unilateral exudative AMD, focusing particularly on eyes with only pigmentary abnormality. METHODS This study is a retrospective observational conse...

Journal: :Investigative ophthalmology & visual science 2014
Bum-Joo Cho Jang Won Heo Tae Wan Kim Jeeyun Ahn Hum Chung

PURPOSE To investigate the prevalence and risk factors of age-related macular degeneration (AMD) in the general Korean adult population. METHODS The study involved a nationally representative Korean population from the 2010 to 2011 Korea National Health and Nutrition Examination Survey. A total of 7899 subjects ≥ 40 years old participated in health interviews, physical examinations, and ophth...

2015
Paul D. Loprinzi Bonnielin K. Swenor Pradeep Y. Ramulu

BACKGROUND We have a limited understanding of the effects of age-related macular degeneration (AMD) on physical activity (PA), and we have no prevalence estimates of the daily movement patterns among Americans with AMD. Therefore, we examined the association between AMD and PA and provided estimates of the daily movement patterns of Americans with AMD. METHODS Data from the 2005-2006 National...

Journal: :molecular and biochemical diagnosis (journal) 2014
saghar yousefnia

background: cells have complex network of antioxidant enzymes that protect cells from induced damages by reactive oxygen species (ros). catalase and superoxide dismutase are known for their role as primary protection against oxidative stress. oxidative damage is an important risk factor in age-related macular degeneration disease (amd). for the first time in this study the impact of genetic pol...

2012
Mei Chen Heping Xu

The macula or macula lutea (originally from Latin macula, “spot” and lutea, “yellow”) is an oval-shaped spot, five mm in diameter, located temporal to the optical nerve and near the centre of the human retina. Although it comprises only a small part of the retina, it is responsible for the sharp central vision and colour vision. Age-related macular degeneration (AMD) is a disease in which the n...

2015
James Loughman Sarah Sabour-Pickett John M. Nolan Barbara Klein Ronald Klein Stephen Beatty

PURPOSE To investigate the relationship between visual function and severity of early age-related macular degeneration (AMD) and activity of neovascular (nv-) AMD. METHODS The following data was collected from 66 eyes of 66 subjects with early AMD and 47 eyes of 47 subjects with active nv-AMD: corrected distance visual acuity (CDVA); contrast sensitivity (CS); glare disability (GD); and retin...

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