نتایج جستجو برای: بزرگراه a20 فرانسه

تعداد نتایج: 5525  

Journal: :EMBO reports 2014
Arnab De Teruki Dainichi Chozha Vendan Rathinam Sankar Ghosh

A20 has been suggested to limit NF-κB activation by removing regulatory ubiquitin chains from ubiquitinated substrates. A20 is a ubiquitin-editing enzyme that removes K63-linked ubiquitin chains from adaptor proteins, such as RIP1, and then conjugates them to K48-linked polyubiquitin chains to trigger proteasomal degradation. To determine the role of the deubiquitinase function of A20 in downre...

2015
Peter Draber Sebastian Kupka Matthias Reichert Helena Draberova Elodie Lafont Diego de Miguel Lisanne Spilgies Silvia Surinova Lucia Taraborrelli Torsten Hartwig Eva Rieser Luigi Martino Katrin Rittinger Henning Walczak

Ubiquitination and deubiquitination are crucial for assembly and disassembly of signaling complexes. LUBAC-generated linear (M1) ubiquitin is important for signaling via various immune receptors. We show here that the deubiquitinases CYLD and A20, but not OTULIN, are recruited to the TNFR1- and NOD2-associated signaling complexes (TNF-RSC and NOD2-SC), at which they cooperate to limit gene acti...

2011
Scott M. Damrauer Peter Studer Cleide G. da Silva Christopher R. Longo Haley E. Ramsey Eva Csizmadia Gautam V. Shrikhande Salvatore T. Scali Towia A. Libermann Manoj K. Bhasin Christiane Ferran

BACKGROUND Liver regeneration is clinically of major importance in the setting of liver injury, resection or transplantation. We have demonstrated that the NF-κB inhibitory protein A20 significantly improves recovery of liver function and mass following extended liver resection (LR) in mice. In this study, we explored the Systems Biology modulated by A20 following extended LR in mice. METHODO...

2014
Jinyue Hu Guihua Wang Xueting Liu Lina Zhou Manli Jiang Li Yang

A20 functions to terminate Toll-like receptor (TLR)-induced immune response, and play important roles in the induction of lipopolysacchride (LPS)-tolerance. However, the molecular mechanism for Pam3CSK4-tolerance is uncertain. Here we report that TLR1/2 ligand Pam3CSK4 induced tolerance in monocytic THP-1 cells. The pre-treatment of THP-1 cells with Pam3CSK4 down-regulated the induction of pro-...

1999
Karen Heyninck Dirk De Valck Wim Vanden Berghe Wim Van Criekinge Roland Contreras Walter Fiers Guy Haegeman Rudi Beyaert

The zinc finger protein A20 is a tumor necrosis factor (TNF)– and interleukin 1 (IL-1)-inducible protein that negatively regulates nuclear factor-kappa B (NFk B)–dependent gene expression. However, the molecular mechanism by which A20 exerts this effect is still unclear. We show that A20 does not inhibit TNFinduced nuclear translocation and DNA binding of NFk B, although it completely prevents ...

2004
Soizic Daniel Maria B. Arvelo Virendra I. Patel Christopher R. Longo Gautam Shrikhande Tala Shukri Jerome Mahiou David W. Sun Christina Mottley Shane T. Grey Christiane Ferran

A20 is a stress response gene in endothelial cells (ECs). A20 serves a dual cytoprotective function, protecting from tumor necrosis factor (TNF)–mediated apoptosis and inhibiting inflammation via blockade of the transcription factor nuclear factor– B (NFB). In this study, we evaluated the molecular basis of the cytoprotective function of A20 in EC cultures and questioned whether its protective ...

2015
Katharina Troppan Sybille Hofer Kerstin Wenzl Markus Lassnig Beata Pursche Elisabeth Steinbauer Marco Wiltgen Barbara Zulus Wilfried Renner Christine Beham-Schmid Alexander Deutsch Peter Neumeister

Multiple myeloma (MM) is a malignant clonal expansion of plasma cells in the bone marrow and belongs to the mature B-cell neoplams. The pathogenesis of MM is associated with constitutive NF-κB activation. However, genetic alterations causing constitutive NF-κB activation are still incompletely understood. Since A20 (TNFAIP3) is a suppressor of the NF-κB pathway and is frequently inactivated in ...

2015
Masahiro Marshall Nakagawa Keyur Thummar Jonathan Mandelbaum Laura Pasqualucci Chozha Vendan Rathinam

A balance between quiescence and proliferation is critical for proper maintenance of the hematopoietic stem cell (HSC) pool. Although a lot is known about hematopoiesis, molecular mechanisms that control HSC quiescence remain largely unknown. The ubiquitin-editing enzyme A20 functions as a central regulator of inflammation and adaptive immunity. Here, we show that a deficiency of A20 in the hem...

2015
Yimin Wang Ming Wan Qingxin Zhou Hao Wang Zhidong Wang Xiangyu Zhong Lei Zhang Sheng Tai Yunfu Cui Yves St-Pierre

As an antagonist of the JAK/STAT pathway, suppressor of cytokine signaling 3 (SOCS3) plays an integral role in shaping the inflammatory environment, tumorigenesis and disease progression in cholangiocarcinoma (CCA); however, its prognostic significance remains unclear. Although tumor necrosis factor α-induced protein 3 (TNFAIP3, also known as A20) can decrease SOCS3 expression and is involved i...

2010
Gautam V. Shrikhande Salvatore T. Scali Cleide G. da Silva Scott M. Damrauer Eva Csizmadia Prabhakar Putheti Michaela Matthey Roy Arjoon Rakesh Patel Jeffrey J. Siracuse Elizabeth R. Maccariello Nicholas D. Andersen Thomas Monahan Clayton Peterson Sanah Essayagh Peter Studer Renata Padilha Guedes Olivier Kocher Anny Usheva Aristidis Veves Elzbieta Kaczmarek Christiane Ferran

BACKGROUND Accelerated atherosclerosis is the leading cause of morbidity and mortality in diabetic patients. Hyperglycemia is a recognized independent risk factor for heightened atherogenesis in diabetes mellitus (DM). However, our understanding of the mechanisms underlying glucose damage to the vasculature remains incomplete. METHODOLOGY/PRINCIPAL FINDINGS High glucose and hyperglycemia redu...

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