There has recently been an increasing research interest in network management infrastructures that autonomously adapt to the dynamics of the environment. In this paper, we present an information management platform, called the Information Management Overlay (IMO), which is an infrastructure that regulates information flow based on the properties and the state of the network environment. We disc...

Purpose: Resistance to anti-HER2 monoclonal antibody trastuzumab is a relevant issue in breast cancer patients. Among the mechanisms implicated in trastuzumab resistance, increasing evidence supports a role of tumor microenvironment. We previously found that a novel toll-like receptor 9 agonist, referred to as immune modulatory oligonucleotide (IMO) and currently under clinical investigation, a...

Atopic dermatitis (AD) and stress create a vicious cycle: stress exacerbates atopic symptoms, and atopic disease elicits stress and anxiety. Targeting multiple pathways including stress and allergic inflammation is, therefore, important for treating AD. In this study, we investigated the remedial value of Polygala tenuifolia Willd. (PTW) for treating immobilization (IMO) stress-exacerbated atop...

Andrés, Rosa, Octavi Martı́, and Antonio Armario. Direct evidence of acute stress-induced facilitation of ACTH response to subsequent stress in rats. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R863–R868, 1999.—To determine the role of glucocorticoids in the appearance of the facilitatory effect of stress on the ACTH response to a subsequent stress, sham-operated (Sham) rats ...

In our previous communication we reported the enzymatic recognition of unnatural imidazopyridopyrimidine:naphthyridine (Im:Na) base pairs, i.e. ImO(N):NaN(O) and ImN(O):NaO(N), using the Klenow fragment exo(-) [KF (exo(-))]. We describe herein the successful results of (i) improved enzymatic recognition for ImN(O):NaO(N) base pairs and (ii) further primer extension reactions after the Im:Na bas...

Introduction The use of fossil fuels as an energy source results in the emission of a complex mixture of gases, aerosols and particulate matter to the atmosphere. Legislation to limit these emissions has been implemented both on land and at sea in order to safeguard human health and the environment. However, such legislation began to be implemented earlier for land-based emissions than for emis...

Some extensions of an inequality from IMO’2001 are proven by means of the Lagrange multiplier criterion.

To determine the role of glucocorticoids in the appearance of the facilitatory effect of stress on the ACTH response to a subsequent stress, sham-operated (Sham) rats and rats adrenalectomized (ADX) and supplemented with 50 mg/l corticosterone (B) in the drinking saline (ADX + B) were subjected to 1 min of immobilization stress (Imo) four consecutive times with an interstressor interval of 90 m...

This paper uses support vector machines (SVM) based learning algorithm to select important variables that help explain the realtime peak electricity price in the Ontario market. The Ontario market was opened to competition only in May 2002. Due to the limited number of observations available, finding a set of variables that can explain the independent power market of Ontario (IMO) real-time pea...

The involvement of the nonclassical renin-angiotensin system (RAS) in the adrenomedullary response to stress is unclear. Therefore, we examined basal and immobilization stress (IMO)-triggered changes in gene expression of the classical and nonclassical RAS receptors in the rat adrenal medulla, specifically the angiotensin II type 2 (AT2) and type 4 (AT4) receptors, (pro)renin receptor [(P)RR], ...