The discovery of endogenous opiates in 1975 (1) generated considerable research concerning the effects of exercise on the release of these peptides, particularly on -endorphin, which represents the main focus of this chapter. Previous research considered changes in peripheral blood concentrations induced by different modes of physical activity, influences of training status on the secretion of ...

Abstract Taking the humoral body as its spatial focus, this article considers how medical writers and practitioners engaged with ‘intoxicants’ both in terms of prescription medicines conceptualization compulsive consumption – or what is often styled by modern ‘addiction’. Focusing first instance on compilers vernacular pharmacopoeia compilations ingredients techniques argues that just sugar, to...

This study reviews opiates (endorphin agonists) in treatment of pain and addiction with specific focus on their addictive potential versus benefits. This review suggests endorphin agonists enjoy mood stabilizing and antidepressant properties and have been helpful in treatment of pain, mood and addictive disorders. The evidence is consistent with the observation that slow release opiate preparat...

Black widow spider envenomation (BWSE) is commonly associated with severe abdominal pain, muscle cramping, and hypertension. Treatment is primarily symptomatic with the use of opiates and benzodiazepines. Priapism is a complication of BWSE that has only rarely been reported. We describe a 17-month-old male who developed priapism after known BWSE. His priapism did not respond to opiates or benzo...

Submit Manuscript | http://medcraveonline.com J Psychol Clin Psychiatry 2015, 3(4): 00144 death [1]. There have been several recent publications consistent with premature deaths associated with discontinuation of opiates independent of withdrawal induced adverse events [2-4]. There is also compelling neuro imaging evidence of brain atrophy associated with chronic pain and depression [5-6]. A nu...

objectives: early maladaptive schemas are valid representations of unpleasant childhood experiences that shape a person’s viewpoints of the world, and lead to clinical symptoms such as depression, personality disorders, and substance abuse. given the importance of this matter, we conducted a research on early maladaptive schemas in substance-abusers, to allow more appropriate preventive measure...

immunoassay, whereas the Syva and Genix assays are one-step immunochromatographic assays for rapid detection of opiates in urine with a cutoff concentration of 300 mg/L. Information about rifampin cross-reactivity with these immunoassays was not available from the manufacturers. The only reported interference for rifampin is with the opiates kinetic interaction of microparticles in solution (KI...

Ultra-low-dose opioid antagonists, when combined with opiates, increase the analgesic efficacy and duration of analgesia of the opiate. This enhanced and prolonged analgesia was recently demonstrated in a 350-patient Phase II clinical trial of Oxytrex, a novel drug candidate that combines oxycodone with an ultra-low dose of the opioid antagonist naltrexone. Extensive preclinical data also show ...

PURPOSE We tested the hypothesis that prescription coverage affects the prescribing of long-acting opiates to indigent inner city minority patients with cancer pain. MATERIALS AND METHODS We conducted a chart review of 360 patients treated in the Oncology Practice at University of Medicine and Dentistry of New Jersey University Hospital, who were prescribed opiate pain medications. Half the p...

Chronic exposure to opiates eventually leads to drug addiction, which is believed to involve maladaptive changes in brain function, but the underlying neuronal mechanisms remain primarily unknown. Given the known effects of opiates such as morphine and heroin on hippocampal function, we investigated the potential effect of chronic opiate treatment on long-term potentiation (LTP) at CA1 synapses...