Treatment of tinnitus with tinnitus coping therapy, tinnitus maskers, tinnitus retraining therapy, customized sound therapy, transcranial magnetic stimulation, transcranial direct current stimulation, transcutaneous electrical stimulation of the ear, transmeatal laser irradiation, electromagnetic energy, and botulinum toxin type A injections is considered investigational, as there is insufficie...

In patients with cerebral malaria (CM), higher levels of cell-specific microparticles (MP) correlate with the presence of neurological symptoms. MP are submicron plasma membrane-derived vesicles that express antigens of their cell of origin and phosphatidylserine (PS) on their surface, facilitating their role in coagulation, inflammation and cell adhesion. In this study, the in vivo production,...

AIMS The aim of this study was to establish whether pharmacokinetic differences between two pro-drugs of methylprednisolone (MP) are likely to be of clinical significance. METHODS This study was a single-blind, randomized, crossover design comparing the bioequivalence of MP released from the pro-drugs Promedrol (MP suleptanate) and Solu-Medrol (MP succinate) after a single 250 mg (MP equivale...

This study evaluated the effect of a combination of mannan-oligosaccharides (MOS) and microbial phytase (MP) on growth performance, some blood biochemical metabolites, intestinal morphology and cecal microbial population of ROSS 308 broiler chickens from d 0 to 35 of age. A total of 200 one-dayold broiler chickens (mixed sex) were randomly distributed into four treatments with five replicates a...

Gliomas are highly aggressive and accompanied by numerous microglia/macrophages (MG/MP) in and about the tumor. Little is known about what MG/MP do in this setting, or whether modulating MG/MP activation might affect glioma progression. Here, we used a glioma-microglia in culture system to establish the effects the tumor and microglia have on each other. We assessed glioma progression in vivo a...

This work proposes an original approach to musical score recognition, a particular case of highlevel document analysis. In order to overcome the limitations of existing systems, we propose an architecture which allows for a continuous and bidirectional interaction between high-level knowledge and low-level data, and which is able to improve itself over time by learning. This architecture is mad...

OBJECTIVE The alcohol dehydrogenase inhibitor 4-methylpyrazole (4-MP) is a new antidote of ethylene glycol (EG) intoxication. The purpose of the present case report was to demonstrate 4-MP efficiency in EG poisoning in a 4-year-old child. METHOD AND RESULTS 4-MP Treatment was performed 7 hours after EG ingestion. Plasma EG and 4-MP concentrations were measured 2 hours after each infusion of 4...

Methylphenidate (MP) (Ritalin) is widely used for the treatment of attention deficit hyperactivity disorder (ADHD). It is a chiral drug, marketed as the racemic mixture of d- and l-threo enantiomers. Our previous studies (PET and microdialysis) in humans, baboons, and rats confirm the notion that pharmacological specificity of MP resides predominantly in the d-isomer. A recent report that intra...