We have used in situ hybridisation to establish the temporal and spatial expression patterns of the mouse homeobox-containing gene; Hox-7, in the developing embryonic cranium and nervous system of the mouse between embryonic days 9.5 (E9.5) and E15.5. Hox-7 has previously been associated with areas of mesenchymal-epithelial interaction and cell migration especially in neural crest ectomesenchym...

Results 45.7% had successful pregnancy outcome. 40% cases had missed abortion. Five patients chose to have Medical Termination of Pregnancy (MTP) with tubal ligation. The majority of subjects (76.4%) delivered within 5 years of valve replacement. Despite counselling about embryopathy all except one patient continued to take oral anticoagulants. There was no maternal mortality. Morbidity in the ...

UNLABELLED Human reproduction is not considered a highly efficient biological process. Before the end of the first trimester, 30%-50% of conceptions end in spontaneous abortion. Most losses occur at the time of implantation. 15%-20% of clinical pregnancies end in spontaneous abortions. Recurrent pregnancy loss is a frustrating clinical problem both for clinicians and patients. Recurrent pregnan...

The incidence as well as the current state of the management of the limb deficient child in Japan is described. General medical and welfare services in Japan The medical service system in Japan is well organized and includes the diagnosis, treatment and follow-up care of limb deficient children. Once the child has been diagnosed as physically disabled due to limb deficiencies and/or congenital ...

A single intraperitoneal injection (0.6 ml/kg) of dimethoxyethyl phthalate (DMEP) was given to groups of Wistar strain rats on day 10, 11, 12, 13 or 14 of gestation. Control rats received 0.6 ml/kg of physiological saline intraperitoneally. In phthalate-treated rats, embryopathy was manifested by a high incidence (12-79%) of fetal deaths and fetal resorptions. Fetotoxic effects were expressed b...

We have recently shown that Okihiro syndrome results from mutation in the putative zinc finger transcription factor gene SALL4 on chromosome 20q13.13-13.2. There is considerable overlap of clinical features of Okihiro syndrome with other conditions, most notably Holt-Oram syndrome, a condition in part resulting from mutation of the TBX5 locus, as well as acro-renal-ocular syndrome. We analysed ...

BACKGROUND Thalidomide is known to have induced thalidomide embryopathy (TE) in more than 10,000 live-born children worldwide between 1957-1962. AIM The aim of this study was to investigate the need for orthopaedic surgery and limb orthosis in relation to function and physical independence in middle-aged individuals with TE. METHODS 13 women/18 men with a mean age of 45.8 (SD 1.1) years wer...

In this issue of the Journal of Infectious Diseases, 2 articles by Kesebir and colleagues at Yale–New Haven Hospital and Yale University School of Medicine (New Haven, Connecticut) [1] and by Manning and colleagues at the Royal Infi mary of Edinburgh (Edinburgh, United Kingdom) [2] describe the detection, primarily in hospitalized infants, of human bocavirus (HBoV) in respiratory tract samples ...

INTRODUCTION Hyperthyroidism in pregnancy is a serious condition and its management is complex. Whilst carbimazole/methimazole (CBZ/MMI) and propylthiouracil (PTU) have similar efficacies in controlling hyperthyroidism, their risk of side effects such as major congenital abnormalities and hepatotoxicity are different. METHODS Various combinations of the terms 'anti-thyroid drugs', 'thionamide...

BACKGROUND Pregnant patients with mechanical heart valves require anticoagulation. The risk of bleeding and embryopathy associated with oral anticoagulants must be weighed against the risk of valve thrombosis. METHODS In this prospective study, undertaken between 1999 and 2009, 53 pregnancies (47 women with mechanical mitral valves; 29.8 ± 4.8 years old) were studied. Patients were divided in...