Excessive generation of wear particles after total joint replacement may lead to local inflammation and periprosthetic osteolysis. Modulation of the key transcription factor NF-κB in immune cells could potentially mitigate the osteolytic process. We previously showed that local delivery of ultrahigh-molecular-weight polyethylene (UHMWPE) particles recruited osteoprogenitor cells and reduced ost...

Ultra-high molecular weight polyethylene (UHMWPE) has been widely used as acetabular cup in total hip replacement (THR) and tibial component in total knee replacement (TKR). Crosslinking of UHMWPE has been successful used to improve its wear performance leading to longer life of orthopedic implants. Crosslinking can be performed by radiation or organic peroxides. Peroxide crosslinking is a conv...

The introduction of numerous formulations of Ultra-high molecular weight polyethylene (UHMWPE), which is widely used as a bearing material in orthopedic implants, necessitated screening of bearing couples to identify promising iterations for expensive joint simulations. Pin-on-disk (POD) testers capable of multidirectional sliding can correctly rank formulations of UHMWPE with respect to their ...

Ultra high molecular weight polyethylene (UHMWPE) is a material commonly used in total hip and knee joint replacements. Numerous studies have assessed the effect of its viscoelastic properties on phenomena such as creep, stress relaxation, and tensile stress. However, these investigations either use the complex 3D geometries of total hip and knee replacements or UHMWPE test objects on their own...

With recent improvements to the properties of ultra-high molecular weight polyethylene (UHMWPE) used in joint replacements, prosthetic knee and hip longevity may extend beyond two decades. However, it is difficult and costly to replicate such a long in vivo lifetime using clinically relevant in vitro wear testing approaches such as walking gait joint simulators. We advance a wear test intermedi...

This article aims to investigate the influence of reinforcing graphene oxide (GO) and graphite flakes (GF) fillers into ultrahigh molecular weight polyethylene (UHMWPE) for orthopedic application. These were expected physically bond UHMWPE, thus can enhance subsurface strength, improving wear behavior composites. UHMWPE/GO UHMWPE/GF composites prepared at 0.1 1.0 wt% by melt-blending, followed ...

INTRODUCTION Wear of ultra-high molecular weight polyethylene (UHMWPE) in total knee replacements remains a major limitation to the longevity of these clinically successful devices [1]. Improvements in sterilization techniques over the past decade have reduced oxidative degradation of the UHMWPE bearing, with potentially dramatic long-term reductions in fatigue-related pitting and delamination ...

The average life span of knee prosthesis used in Total Knee Replacement (TKR) is approximately 10 to 15 years. Literature indicates that the reasons for implant failures include wear, infection, instability, and stiffness. However, the majority of failures are due to wear and tear of the prosthesis. The most common biopolymer used in TKR  is Ultra High Molecular Weight Polyethylene (UHMWPE). Pr...

The aim of this study was to evaluate the friction and wear behavior of ultra high molecular weight polyethylene (UHMWPE) against 3Y-TZP and a novel 3Y-TZP/niobium (Nb) biocomposite. The ceramic and the biocomposite materials were subjected to an accelerated aging process to evaluate the changes in the tribological behavior after this treatment. To carry out the tribological tests, a reciprocat...

New colorimetric methods are described for determination of sub-milligram amounts of ultra-high molecular weight polyethylene (UHMWPE) wear particles. These methods are based on the irreversible binding of the fluorescein-conjugated bovine serum albumin or the hydrophobic dye Oil Red O to wear particles. UHMWPE particles bind both substances from their solutions and thus decrease the absorbance...