I was very honored to receive the University of California, San Francisco, and the International Society of Pharmacometrics Lewis Sheiner lecturer award in May 2013. In the present perspective, I outline the main points of my lecture at the American Conference of Pharmacometrics (slides in Supplementary Material 1). I first emphasize the scientific contributions of Lewis Sheiner as a quantitati...

8-puzzle is typically solved by heuristic search. Real-time heuristic search usually gives better results when searching deeper. But sometimes deeper search leads to worse results than shallower which is a phenomenon called search pathology. In this paper we present the results of our investigation of the causes for pathology in 8-puzzle and some of its variations.

CuCl has been successfully immobilized on a novel diamide modified SBA-15, and proven to be an efficient heterogenized catalyst for the oxidative carbonylation of methanol to dimethylcarbonate.

Human interleukin-15 (hIL-15) and its receptor α (hIL-15Rα) are co-expressed in antigen presenting cells allowing trans-presentation of the cytokine to immune effector cells. We exploited the high-affinity interactions between hIL-15 and the extracellular hIL-15Rα sushi domain (hIL-15RαSu) to create a functional scaffold for the design of multispecific fusion protein complexes. Using single-cha...

A new pseudo-tetrahedral Co(II) complex has been grafted onto the surface of SBA-15 and successfully utilized for the catalytic oxidization of alkylaromatic substrates with tert-butyl hydroperoxide (TBHP)via an H-atom transfer mechanism.

Fusarium graminearum Z-3639 and F. sporotrichioides NRRL3299 produce the trichothecene mycotoxins 15-acetyldeoxynivalenol and T-2 toxin, respectively. These toxins differ in oxygenation at C-4, C-7, and C-8. In F. sporotrichioides, Tri1 (FsTri1) controls C-8 hydroxylation. To determine the function of an apparent F. graminearum Tri1 (FgTri1) homolog, both FsTri1 and FgTri1 genes were heterologo...

The generation and maintenance of immunological memory requires the activation, expansion, and persistent proliferation of antigen-specific T cells. Recent work suggests that IL-15 may be important for this process. Surprisingly, we now find that expression of the high-affinity receptor for IL-15, IL-15R , on T cells is dispensable for the generation or maintenance of memory CD8 T cells. By con...

بررسی تلاش های سازمان ملل متحد، در دو حوزه یافزایش حقوق زنان و نگاه داری از محیط زیست، گویای اهمیت بسیار زیاد مشارکت زنان در گستره بین المللی است. نقش دهی به زنان و سازمان های غیردولتی آنان، در نگاه داری از محیط زیست و دست یابی به توسعه پایدار، اهمیتی به سزا دارد و به همین دلیل، اسناد گوناگون بین المللی، مشارکت این بازیگران را مورد شناسایی قرار داده است.پژوهش پیش رو، در پی مطالعه جای گاه زنان د...

Background Interleukin-15 (IL-15) mediates the function of some innate and adaptive immune cells, which makes it an attractive target as an anti-cancer agent. Gene electrotransfer (GET) has been used to safely deliver plasmid DNA (pDNA) to tissues in a number of pre-clinical and clinical studies for cancer therapy. Previously we have shown using GET to deliver interleukin-15 (IL-15) to mouse me...