The USP has proposed using inductively coupled plasma (ICP) for determining heavy metals in drug articles to replace the USP <231> heavy metals test. While the current USP <231> procedure will detect Pb, Hg, Bi, As, Sb, Sn, Cd, Ag, Cu and Mo, the proposed method will test for Al, Sb, As, Be, B, Cd, Cr, Co, Cu, In, Ir, Fe, Pb, Li, Mg, Mn, Hg, Mo, Ni, Os, Pd, Pt, Rh, Rb, Ru, Se, Sr, Tl, Sn, W and...

1Ophthalmology and Otorhinolaryngology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo USP – São Paulo (SP), Brazil. 2Ophthalmology and Otorhinolaryngology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo USP – São Paulo (SP), Brazil. 3Head of Strabismus Department. Ophthalmology and Otorhinolaryngology Department, H...

Accepted: April 03, 2015 Study carried out at the Audiology Sector of the University Hospital, Universidade de São Paulo – USP São Paulo (SP), Brazil. 1 Department of Physical Therapy, Speech-Language Pathology and Audiology and Occupational Therapy, School of Medicine, Universidade de São Paulo – USP São Paulo (SP), Brazil. 2 University Hospital, Universidade de São Paulo – USP São Paulo (SP),...

First submission on 23/05/13; last submission on 01/06/13; accepted for publication on 17/06/13; published on 20/12/13 1. MSc by the Clinical Analysis Department Faculty of Pharmaceutical Sciences Universidade de São Paulo (USP). 2. Post-doctorate in Sciences by Instituto de Química da USP; professor at the Microbiology Department Biomedical Sciences InstituteUSP and at the Clinical Analysis De...

The ultraspiracle (usp) gene encodes a nuclear receptor that forms a heterodimer with the ecdysone receptor (EcR) to mediate transcriptional responses to the insect steroid hormone, 20-hydroxyecdysone (20HE). The responses ultimately elicit changes associated with molting and metamorphosis. Although Ultraspiracle (USP) is required at several developmental times, it is unclear whether USP plays ...

Laboratory methods to improve smear microscopy are an urgent priority for global tuberculosis control. The novel universal sample processing (USP) method has been reported to improve conventional diagnostic testing for tuberculosis while also providing inhibitor-free specimens for molecular assays. However, no studies evaluating the method in the field have been conducted. In this study, we com...

Heterodimerization of nuclear receptors is facilitated by the interaction of two dimerization interfaces: one spanning the DNA-binding (C domain) region and the adjacent hinge (D domain) region, and the other in the ligand-binding (E domain) region. Ultraspiracle (USP) heterodimerizes with ecdysone receptor (EcR) and this complex participates in ecdysone signal transduction. The natural ecdyson...

Having validated analysis methods for medicinal ingredients is attractive for pharmaceutical companies. When a new molecule is introduced to the market, there is not any pharmacopeial analysis method for that. After publishing official methods, correlation between validated in-house methods and the official one could stablish the value of the in-house method. Sitagliptin phosphate is a new anti...

The performance of the analytical methodologies recommended by the United States Pharmacopoeia (USP) monograph (1) for dissolution testing of lansoprazole (LPZ) enteric-coated solid dosage forms (capsules/tablets) was critically evaluated. While USP adopts an essentially nonselective UV method, the British Pharmacopoeia (2) recommends a highperformance liquid chromatography (HPLC) method capabl...

The steroid hormone 20-hydroxyecdysone (20E) initiates metamorphosis in insects by signaling through the ecdysone receptor complex, a heterodimer of the ecdysone receptor (EcR) and ultraspiracle (USP). Analysis of usp mutant clones in the wing disc of Drosophila shows that in the absence of USP, early hormone responsive genes such as EcR, DHR3 and E75B fail to up-regulate in response to 20E, bu...