engineering – procurement and construction (epc) contract is one of the current contracts in the today world. when governmental sector trends to use the expertise of domestic or foreign private in engineering and construction of infrastructural projects, finds epc contract as a suitable legal frame. in this article, we have tried to discuss about the most important legal aspects of this kind of...

Endothelial progenitor cells (EPC) are bone-marrow derived circulating cells participating in angiogenesis and vascular homeostasis. Reduced numbers of circulating EPC are observed in patients with various cardiovascular diseases and are related to an increased risk for future cardiovascular events and death. Little is known about functional changes. The aim of this thesis was to study the func...

BACKGROUND EPC number and functionality are assumed to reflect the endogenous vascular repair capacity with the EPC pool declining in higher ages and being exhausted by unfavorable life-style and risk factors. This intriguing and clinically highly relevant concept, however, has so far been derived from small case-control studies and patient series. METHODOLOGY AND PRINCIPLE FINDINGS In the po...

Transplantation of bone marrow cells as well as circulating endothelial progenitor cells (EPC) enhances neovascularization after ischemia. The chemokine receptor CXCR4 is essential for migration and homing of hematopoietic stem cells. Therefore, we investigated the role of CXCR4 and its downstream signaling cascade for the angiogenic capacity of cultured human EPC. Ex vivo, differentiated EPC d...

A graph G is quadrangularly connected if for every pair of edges e1 and e2 in E(G), G has a sequence of l-cycles (3 ≤ l ≤ 4) C1, C2, ..., Cr such that e1 ∈ E(C1) and e2 ∈ E(Cr) and E(Ci) ∩ E(Ci+1) 6= ∅ for i = 1, 2, ..., r − 1. In this paper, we show that every quadrangularly connected claw-free graph without vertices of degree 1, which does not contain an induced subgraph H isomorphic to eithe...

We present a study of disordered jammed hard-sphere packings in four-, five-, and six-dimensional Euclidean spaces. Using a collision-driven packing generation algorithm, we obtain the first estimates for the packing fractions of the maximally random jammed (MRJ) states for space dimensions d=4, 5, and 6 to be phi(MRJ) approximately 0.46, 0.31, and 0.20, respectively. To a good approximation, t...

Disorazoles comprise a family of 29 macrocyclic polyketides isolated from the fermentation broth of the myxobacterium Sorangium cellulosum. The major fermentation product, disorazole A1, was found previously to irreversibly bind to tubulin and to have potent cytotoxic activity against tumor cells, possibly because of its highly electrophilic epoxide moiety. To test this hypothesis, we synthesiz...

Considering the therapeutic values of bioflavonoids in colon cancer treatment, six 2'-hydroxy chalcones (C1-C6) were synthesized, characterized and screened for in vitro cytotoxicity on human colon carcinoma (HCT116) and African green monkey kidney epithelial cells (Vero). Only C5 showed selective cytotoxicity against HCT116 cells. Other potent cytotoxic compounds were C1, C2 and C3. Further sc...