We have developed a rat model of ischemic bowel necrosis associated with shock by injection of platelet-activating factor (PAF) or a combination of PAF and endotoxin. Recent investigations have shown that tumor necrosis factor (TNF) also induces shock and necrosis of the gastrointestinal tract. The morphological changes of TNF-induced bowel lesions are indistinguishable from those caused by PAF...

Intrasplenic administration of a colon adenocarcinoma cell line, colon 26, induced tumor necrosis factor (TNF) alpha protein expression around the central and portal veins of the liver at 3 days, and liver metastases by 24 days after the tumor injection, in 90% of wild-type (WT) mice. To explore the roles of TNF-alpha in the process, we administered colon 26 cells into tumor necrosis factor rec...

Introduction:The aim of this study was to investigate the effect of fasting in Ramadan on visfatin, tumor necrosis factor alpha (TNF-α) and adiponectin level in human. Methods:Thirty four men aged 24 to 55 years old were selected from those people who were willing to fast in Ramadan. The blood sample was obtained from each participant in fasting state at the beginning and the end of study to d...

Tumor necrosis factor alpha (TNF-α) expression amplifies to excess amounts in several disorders such as rheumatoid arthritis and psoriasis. Although, Anti-TNF biologics have revolutionized the treatment of these autoimmune diseases, formation of anti-drug antibodies (ADA) has dramatically affected their use. The next generation antibodies (e.g. Fab, scFv) have not only reduced resulted immunoge...

background and aims: plants as medicines have always played a vital role in human life. tumor necrosis factor alpha (tnf)-α is one of the macrophage-derived inflammatory cytokine with pleotropic effects in the inflammation process. some studies have been demonstrated that some of the echinops species have anti-inflammatory activity. in fact, echinops lasilepis is introduced as one of the native...

conclusions the results indicated that there was a positive association between susceptibility to chronic hbv infection and tnf-α polymorphism. in addition, hbv patients carrying -308 gg, -857 cc, and -863 aa genotypes with lower serum levels of tnf-α had an increased risk of infection. background the host genetic background regulates the natural history of chronic hepatitis b virus (hbv) infec...