INTRODUCTION Limited data suggest mild hypernatremia may be related to lower intracranial pressure (ICP) in patients with traumatic brain injury (TBI). The practice at the study center has been to use hypertonic saline (HTS) to generate a targeted serum sodium of 145 to 155 mEq/l in patients with TBI. The purpose of this study was to determine the relationship between serum sodium values and IC...

INTRODUCTION The purpose of this study was to determine if noninvasive transcranial oxygen saturation (StcO2) and Bispectral Index (BIS) correlate with severe traumatic brain injury intensive care unit (ICU) outcomes. METHODS This is a prospective observational study. Values of intracranial pressure (ICP), mean arterial pressure (MAP), BIS, and StcO2 were recorded hourly for the first six, po...

Increased intracranial pressure (ICP) is a pathologic state common to a variety of serious neurologic conditions, all of which are characterized by the addition of volume to the intracranial vault. Hence all ICP therapies are directed toward reducing intracranial volume. Elevated ICP can lead to brain damage or death by two principle mechanisms: (1) global hypoxic-ischemic injury, which results...

T. Geeraerts (!) · Y. Launey · L. Martin · J. Pottecher · B. Vigué · J. Duranteau · D. Benhamou University of Paris-Sud, Department of Anesthesiology and Critical Care Medicine, Hospital of Bicêtre, Assistance Publique-Hôpitaux de Paris (AP-HP), Faculty of Medicine, Le Kremlin Bicêtre, 94275 Paris, France e-mail: [email protected] Tel.: +33-1-45213429 Fax: +33-1-45212875 Abstract Obj...

Introduction Raised intracranial pressure (ICP) can cause secondary brain injury, which is associated with severe disability and mortality [1]. Invasive ICP monitoring has been linked to increased mortality [2]. Sekhon, et al. [3] demonstrated a strong correlation between optic nerve sheath diameter (ONSD) on CT scan and ICP, with the potential to use this non-invasive method to detect raised ICP.

The causes of death and neurological sequelae in African children with cerebral malaria are obscure. Intracranial pressure (ICP) was monitored and cerebral perfusion pressure (CPP) calculated in 23 Kenyan children with cerebral malaria. Four children had severe intracranial hypertension (ICP > 40 mm Hg, CPP < 40 mm Hg): two died, one with an ICP of 158 mm Hg and signs of transtentorial herniati...

The introduction and development of Single Particle ICP-MS (SP-ICP-MS) has opened a new area of research which allows the rapid detection and analysis of metal-based particles in a variety of matrices and applications.1-6 The key feature of SP-ICP-MS is that it allows discrete pulses of positively charged ions to be detected and measured in a time-resolved manner using microsecond (μs) data acq...

Introduction Inductively Coupled Plasma Mass Spectrometry (ICP-MS) typically provides detection limits in the low-ppt to sub-ppt range for all but a few of over 70 elements. Unfortunately, for a handful of elements, conventional ICP-MS cannot provide the best possible detection limits. The detection limits for these elements are limited by plasma or sample matrix-based polyatomic interferences....

Slow waves in intracranial pressure (ICP) and related signals seems of interest to evaluate the dynamic autoregulation, i.e. by comparison of the frequency links between an intracranial signal, e.g. ICP, cerebral blood velocity (CBV), and arterial blood pressure (ABP). To clarify the links, we compared two frequency methods based on coherence function to estimate the influence of ICP, ABP and C...