Extracellular matrix (ECM) comprises a rich meshwork of proteins and proteoglycans, which not only contains biological cues for cell behavior, but is also a reservoir for binding growth factors and controlling their release. Here we aimed to create a suitable bony microenvironment with cell-derived ECM and biodegradable β-tricalcium phosphate (β-TCP). More specifically, we investigated whether ...

ite power and grounding audits/evaluations of commercial and industrial locations routinely identify electrical power system grounding and bonding problems. According to S. Frank Waterer, an electrical engineering IEEE Fellow at Schneider Electric with more than 30 years of experience, approximately 70% of all anomalies, dysfunctions, or problems associated with power distribution systems are d...

In This Issue In This Issue cGMP steers axons home n page 489, Schmidt et al. identify a second messenger that helps to steer growth cones. Without this cGMP-directed guidance system, sensory axons lose their way during development. Axonal pathfinding and cyclic nucleotide second messengers have been linked by recent in vitro studies showing that cGMP protects growth cones from collapse induced...

The ability of Candida albicans to adhere to subendothelial extracellular matrix (ECM) may be important in the pathogenesis of disseminated candidiasis. ECM proteins, such as fibronectin, laminin, and types I and IV collagen bind C. albicans avidly. These proteins all possess heparin-binding domains. The influence of the glycosaminoglycans (GAGS) including heparin, heparan sulfate and dextran s...

Fibroblasts can adhere to extracellular matrix (ECM) material by fibronectin-dependent (type I) and fibronectin-independent (type II) mechanisms. In this report we investigate the biochemical characteristics of ECM that contribute to type II adhesion. ECM capable of mediating type II adhesions is produced primarily by normal diploid fibroblasts, but not by transformed cells or epithelial cells....

If the brain is injured due to traumatic injury (TBI), it will lose some of its cells. our cells get damaged, we may be left with problems controlling movement, speech, or even memory! In future, tissue engineering able help people TBI. Tissue involves building a piece outside body assisting damaged part grow again and function inside body. Cells are blocks body, they surrounded by matrix that ...