PURPOSE The DNA methylation inhibitor 5-aza-2'-deoxycytidine (DAC) is approved for the treatment of myelodysplastic syndromes (MDS), but resistance to DAC develops during treatment and mechanisms of resistance remain unknown. Therefore, we investigated mechanisms of primary and secondary resistance to DAC in MDS. PATIENTS AND METHODS We performed Quantitative Real-Time PCR to examine expressi...

PURPOSE To analyse the role of von Hippel-Lindau (VHL) and transforming growth factor β-induced (TGFBI) in synergistic mechanisms of 5-aza-2'-deoxycytidine (DAC) and paclitaxel (PTX) against renal cell carcinoma (RCC). METHODS To elucidate the role in the synergy between DAC and PTX against RCC cells, TGFBI expression was regulated using siRNA technology and an expression vector containing th...

VME based Ion Cyclotron Resonance Heating (ICRH) Data Acquisition Control system (DAC) is commissioned for remote operation of heating experiment on SST-1 tokamak. Linux client software of DAC using has been connected with Ethernet network. DAC client acts as Experimental Physics and Industrial Control System (EPICS) (Input/ Output Controller) IOC server which is used for other Ethernet connect...

P(AM-DAC-BA) was synthesized through copolymerization of acrylamide (AM), acryloyloxyethyl trimethyl ammonium chloride (DAC), and butylacrylate (BA) under ultraviolet (UV) initiation using response surface methodology (RSM). The influences of light intensity, illumination time, and photoinitiator concentration on the intrinsic viscosity [η] of P(AM-DAC-BA) were investigated. RSM model based on ...

Ruan, C.-Q. 2017. Functionalization, Characterization and Applications of Oxidized Nanocellulose Derivatives. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 1548. 68 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0048-1. Cellulose, a sustainable raw material derived from nature, can be used for various applications following its...

In this paper currently used DAC frequency domain parameters definitions are evaluated in order to achieve a consistent terminology that can be used in a DAC standard. New definitions for DAC THD, SFDR, SNR, SINAD and ENOB are proposed taking into account the most used definitions, the need of avoiding any ambiguities and the measurability of them.

Abstract In this paper, discriminative associative classification is proposed as a new technique based on class association rules (CDARs). These are defined itemsets. The itemset frequent in one data and has much higher frequencies compared with the same other classes. CDAR rule (CAR) that support Compared to classification, there additional challenges Apriori property of subset not applicable....

A Distributed Constraint Optimization Problem (DCOP) [7, 6] is a formal framework that can model many cooperative multi-agents domains. The Divide-and-Coordinate (DaC) framework [11] is one of the few general frameworks for solving DCOPs that provides bounds on solution quality for incomplete algorithms. In this paper, we formulate a novel DaC algorithm, the so-called Egalitarian Utilities Divi...

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that resists current treatments. To test epigenetic therapy against this cancer, we used the DNA demethylating drug 5-aza-2'-deoxycytidine (DAC) in an aggressive mouse model of stromal rich PDAC (KPC-Brca1 mice). In untreated tumors, we found globally decreased 5-methyl-cytosine (5-mC) in malignant epithelial cells and in cancer-ass...

BACKGROUND Although MAGE-3 has been detected in approximately 40% of lung and esophageal cancers, expression of this cancer testis antigen appears to be below the threshold for immune recognition in patients with these malignancies. The aim of this study was to determine if the demethylating agent, 5-Aza-2'-deoxycytidine (DAC) and if the histone deacetylase inhibitor Depsipeptide FR901228 (DP) ...