Lupeol and stigmasterol, major phytosterols in various herbal plants, possess anti-inflammatory activities and have been proposed as candidates for anti-cancer agents, but their molecular mechanisms are still unclear. Here, we investigated the effects of lupeol and stigmasterol on tumor and endothelial cells in vitro and their anti-cancer activities in vivo. Our results demonstrated that lupeol...

Plants are excellent sources of secondary metabolites that have been used for the treatment human diseases. The plant Momordica cymbalaria contains different types phytochemicals like phenols, steroids, flavonoids, alkaloids and tannins. present investigation was carried out to determine bioactive compounds in parts by Gas chromatography- Mass spectroscopy (GC-MS) technique. Chromatograms vivo ...

Ethyl acetate fraction column chromatographic analysis was used to isolate eleven compounds (numerically tagged 1–10) from Cassia occidentalis L. in this study. Two unique metabolites, including a neolignan compound designated as occidentalignan I (9) and flavonoidal glycoside, chrysin-7-O-α-L-rhamnopyranosyl (10), were identified, while silybin A (8) the first flavonolignan be isolated Fabacea...

In the present study, stigmasterol has been reported from Pedalium murex L. of pedaliaceae family in vivo and in vitro. Quantification data revealed that the total sterol content was higher in callus than leaves. The in vitro studies showed that the maxmium amount of total sterol was found in 6 weeks old tissue and minimum in 2 weeks old callus culture. In vivo studies showed that higher conten...

The study of the chemical constituents of the whole plant of Erigeron bonariensis (L.) has resulted in the isolation and characterization of a new and nine known compounds. The known compounds were identified as stigmasterol (1), freideline (2), 1,3-dihydroxy-3R,5R-dicaffeoyloxy cyclohexane carboxylic acid methyl ester (3), 1R,3R-dihydroxy4S,5R-dicaffeoyloxycyclohexane carboxylic acid methyl es...

This study examined the thermo-oxidative degradation of stigmasterol fatty acids esters. Stigmasterol stearate, oleate, linoleate and linolenate were synthesized by chemical esterification and their purity evaluated by 1H-NMR and GC-MS. The degradation of stigmasterol esters was examined after heating them at 60 and 180 °C for 1, 2, 4, 8 and 12 h. It was established that stigmasterol esters wer...

The simple terpenes, carotenoids, phytosterols, and flavonoids compositions of the leaves of Acalypha wilkesiana were determined by high performance liquid chromatography (HPLC). The leaves were rich in flavonoids (about 251.3mg/kg dry weight), carotenoids (76.3mg/kg dry weight), and phytosterols (16.6mg/kg dry weight), but very low in simple terpenes (0.0084mg/kg dry weight). Three flavonoids ...