conclusions: hydroxyurea can be safely used in some transfusion-dependent β-thalassemia patients to decrease their transfusion needs. background: β-thalassemia is an inherited hemoglobin disorder caused by defective synthesis of ß-globin chains. hemoglobin (hb) f induction is a possible therapeutic approach which can partially compensate for α and non-α globin chains imbalance. objectives: we a...

background: β-thalassemia is a common autosomal recessive disorder resulting from over 200 different mutations of beta glo­bin genes. the aim of the present study was to identify the distribution and frequency of the most com­mon β-thalassemia mu­tations among the population of isfahan province in central iran. methods: the data presented here were derived from a total of 114 β-thalassemia chro...

background: several cells of immune system such as regulatory t cells and macrophages secrete transforming growth factor-β (tgf-β) in response to different stimuli. this cytokine has inhibitory effect on immune system and diminished production of this cytokine is associated with autoimmune disorders. objective: the aim of this study was to evaluate the influence of opium addiction on serum leve...

background: nowadays, the first step in treatment of ectopic pregnancy (ep) is medical treatment. medical treatment with methotrexate (mtx) for ep is safe and effective method without the risks associated with the surgical procedure. but there are controversies between studies for which patients will respond better to medical treatment. objective: the aim of the present study was to investigate...

In this paper, we define the β-partial derivative as well β-directional of a multi-variable function based on β-difference operator, Dβ, which is defined by Dβf(t)=f(β(t))−f(t)/β(t)−t, where β strictly increasing continuous function. Some properties are proved. Furthermore, β-gradient vector and directional introduced. Finally, deduce Hahn-partial Hahn-directional derivatives associated with Ha...

Precise fitting of the experimental data analyzed separately for each identified crystallographic phase (α, ω, β, β′and β") yield different bulk moduli Bo and Bo’ zero pressure volumes (Vo) than those claimed in literature. Special attention is given to bcc phases indicating cascading transitions β → β’→ β” associated with volume collapse. The present analysis reveals existence a bcc-β′ which r...

Objective: Internet addiction and smartphone are emerging mental health concerns in adolescents. To determine the factors related to these conditions, we investigated their associations with sleep quality, chronotype, patterns, daylight exposure, depression, anxiety.Methods: Self-rated questionnaires, including Addiction Proneness Scale-Short Form, Smartphone Scale–short version, Insomnia Sever...

We consider a Stokes-Magneto system in Rd (d≥2) with fractional diffusions Λ2αu and Λ2βb for the velocity u magnetic field b, respectively. Here α,β are positive constants Λs=(−Δ)s/2 is Laplacian of order s. establish global existence weak solutions any initial data L2 when α, β satisfy 1/2<α<(d+1)/2, β>0, min⁡{α+β,2α+β−1}>d/2. It also shown that unique if β≥1 min⁡{α+β,2α+β−1}≥d/2+1, addition.

Introduction: In any job, performing job tasks requires different psychological demands, physical demands and workload, which can lead to physical and psychological problems in the employee. Therefore, the aim of the current research was to predict the health (organizational stress, health complaints, exhaustion and fatigue) of employees from the psychological demands of the job, physical deman...

abstract β-thalassemia major (β –tm) is the most common thalassemia severe phenotype among iranians. in recent years, molecular understanding of pathogenesis of β –tm has provided a great opportunity regarding diagnostic issues. creating comprehensive molecular databases provides highly sensitive diagnostic tools for β –tm and effective prenatal diagnosis (pnd) molecular screening tests. despit...