Mangosteen, Garcinia mangostana Linn, is a tree found in South East Asia, and its pericarps have been used as traditional medicine. Phytochemical studies have shown that they contain a variety of secondary metabolites, such as oxygenated and prenylated xanthones. Recent studies revealed that these xanthones exhibited a variety of biological activities containing anti-inflammatory, anti-bacteria...

Introduction: Oral Squamous Cell Carcinoma (OSCC) represents approximately 96% of the entire oral cancers. Epithelial-mesenchymal transition (EMT) is a factor contributing to poor prognosis associated with OSCC. α-mangostin one xanthones which show anti-cancer activities against some types cancers and can suppress EMT-induced invasion by increasing E-cadherin expression. This study aimed identi...

Virgin coconut oil (VCO) was used as co-extractant with supercritical carbon dioxide (scCO2) extraction for obtaining xanthones from mangosteen pericarp (MP) without organic co-solvents. In each experiment, 120 g of dried MP that had median particle sizes 0.85 mm used. Extraction 40% VCO using scCO2 (1.08 kg/h) 420 min at 430 bar and 70 °C gave α-mangostin (32.2 mg/g), γ-mangostin (7.2 (28.2 mg...

The present study involves the optimization of different solvent extract and Standardization of α-mangostin from fruit hulls of Garcinia mangostana was studied by gradient reverse-phase high-performance liquid chromatographic (HPLC) method for quality control and quantity determination. Chromatographic separation was carried out on Develosil RP C-18 (5 μm, 4.6 x 150mm) at room temperature using...

Recently colorectal cancer rates have increased rapidly in Taiwan. The treatment of colorectal cancer includes surgery, radiation therapy and chemotherapy. Mangosteen (Garcinia mangostana) is a famous Asian tropical fruit. γ-Mangostin is a xanthone derivative isolated from the fruit hull. In previous studies, we found evidence of anti-inflammatory and anti-brain tumor activities in γ-mangostin....

alpha-Mangostin derived from mangosteen was identified as a mosquito sterol carrier protein-2 inhibitor via high throughput insecticide screening, alpha-Mangostin was tested for its larvicidal activity against third instar larvae of six mosquito species, and the median lethal concentration values range from 0.84 to 2.90 ppm. The residual larvicidal activity of alpha-mangostin was examined under...

We tested the peroxisome proliferator-activated receptor (PPAR)δ agonistic activity of a Garcinia mangostana pericarp extract to develop a treatment for the metabolic syndrome, and demonstrated γ-mangostin to be an active compound on the basis of a luciferase reporter gene assay. γ-Mangostin induced the expression of the uncoupling protein-3 (UCP-3) gene which is related to energy expenditure a...