The aggregation of the â-peptide into amyloid is a key pathological event in Alzheimer’s disease. This process (â-amyloidosis) involves the conversion of soluble random coil, R-helical or â-sheet conformations into insoluble, aggregated â-pleated sheet structures. The pH is a significant extrinsic factor that influences â-amyloidosis, which must be related to the presence of ionizable groups in...

To determine the type of mutation induced by 8-hydroxyguanine in a mammalian system, we examined the mutations induced by a synthetic i -I la-ruv protooncogene containing 8-hydroxyguanine in the second po sition of codon 12 (GGC) in NIH3T3 cells. Transaction of this gene significantly increased the number of transformed foci. The c-Ha-r<w gene present in these foci was analyzed by the polymeras...

 The foreign exchange market (FX market) accounts for 40% of the total volume of the world’s e-commerce by its own. Based on statistics, sometimes up to 90 per cent of the traders lose their total capital in this market just within six months to one year and leave this market. The probability of loss in the FX market can be estimated by probability theory. The present paper intends to demonst...

Thirteen patients with metastatic breast carcinoma were given injec dons of 50—1593@ag of †̃311-monoclonal antibody (MAb) B6.2 immuno globulin G and F(ab')@for pharmacokinetic evaluation and radioimmu noimaging. Blood clearance of the †̃31I-MAb-B6.2 was biphasic. The mean half-times (t@, t@.,)for the immunoglobulin G were 33 ±1.7 and 20.9 ±11.0 h, respectively. The t@ for the F(ab'>@was 1...

â  pathology of theses in the department of arabic language and literature in university of isfahan in its half a century activities â  (a descriptive – analytical study) â â â  somayeh hasan alian * â  sayyedmohammadreza ibnorrasool ** â  â  considering the importance of understanding the history of researches in every field and the necessity of the pathology of these researches to enhance k...

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Three samples of carcinoembryonic antigens were purified from liver métastasesof primary colon cancer. The asparagine-linked sugar chains of carcinoembryonic antigens (CEA) were released as oligosaccharides by hydrazinolysis and the structures of oligosaccharides, thus obtained, was studied in combination with methylation analysis and several limited exoglycosidase digestions. All three CEAs c...

The years 1895 to 1898 were momentous for their impact on health and human well beings. First, Wilhelm Roentgen noted a glowing fluorescent screen, caused by invisible rays. This event subsequently led to the discovery of X-rays in 1895, and thus the birth of the “atomic age”. Next Becquerel’s investigations of these mysterious rays led to his experiments with uranium salt crystals. He th...