Anthrax lethal factor (LF) is a zinc-dependent endopeptidase which, through a process facilitated by protective antigen, translocates to the host cell cytosol in a partially unfolded state. In the current report, the influence of urea and guanidine hydrochloride (GdnHCl) on LF׳s catalytic function, fold and metal binding was assessed at neutral pH. Both urea and GdnHCl were found to inhibit LF ...

Zinc is a micronutrient, which is essential for human health, playing role as a cofactor of enzymes such as dehydrogenases, peptidases and component of zinc finger domains. In organism zinc is involved in metabolic pathways, immune processes, maintaining ion balance between other elements. Recently, it has been reported that zinc may play role in chemoprevention, and its level may be associated...

Y.V. Li and J.H. Zhang (eds.), Metal Ion in Stroke, Springer Series in Translational Stroke Research, DOI 10.1007/978-1-4419-9663-3_7, © Springer Science+Business Media New York 2012 Abstract Although zinc (Zn or Zn 2+ ) signals are necessary for cell communication and survival, abnormal cellular zinc load can be a precursor for cell death and subsequent brain degeneration following a stroke. Z...

Zinc-induced aggregation of the amyloid-β peptide (Aβ) is a hallmark molecular feature of Alzheimer's disease (AD). Recently it was shown that phosphorylation of Aβ at Ser8 promotes the formation of toxic aggregates. In this work, we have studied the impact of Ser8 phosphorylation on the mode of zinc interaction with the Aβ metal-binding domain 1-16 using isothermal titration calorimetry, elect...

Electrosynthesis process has been used for preparation of zinc sulfide nanoparticles. Zinc sulfide nanoparticles in different size and shapes were electrodeposited by electrolysis of zinc plate as anode in sodium sulfide solution. Effects of several reaction variables, such as electrolysis voltage, sulfide ion concentration as reactant, stirring rate of electrolyte solution and temperature on p...

The kinetics of zinc and lead ions removal by modified zeolite-clinoptilolite has been investigated. The rate of the ion exchange process for lead ions is faster than for zinc ions, as well as the time needed to reach the equilibrium. The ion exchange capacity of zeolite of lead ions is doubly higher than that of zinc ions. Diffusion models according to the Vermeulen's approximation, the parabo...

2,2-Bipyridine chelates 2 zinc ions of horse liver alcohol dehydrogenase with a dissociation constant of 4.0 X low4 M. The complex shows an absorption maximum at 308 rnp with a difference extinction coefficient of 1 .l X lo4 M+ cm-r per zinc ion. Because bipyridine binds the enzyme less tightly than o-phenanthroline, and because the principal absorption maximum of the difference spectrum appear...

Optical modeling was applied for obtaining absorbance spectra and band gap values for different morphology of ZnO semiconductor. In optical modeling, the relative permittivity scalars of zinc oxide coral like nanorods were calculated using the Bruggeman homogenization formalism. ZnO nano rods (ZONRs) as a nucleus layer were fabricated on the Indium Tin Oxide (ITO) by chronoamperometry (CA) in a...

Zinc is present in most body cells of human beings, but its concentration is very low. Zinc(II) ion has been widely found in several metalloenzymes such as zinc-peptidases, human carbonic anhydrase and alkalinephosphatase [1]. Today more than 200 different zinc proteins are known which include numerous essential enzymes [2]. Metallothioneins, proteins containing zinc, remain unique in character...