BACKGROUND Many patients with liver malignancies are not candidates for resection, and systemic therapies are often not effective. Radioembolization (RE) is an alternative treatment for this group of patients. The safety and efficacy of RE with yttrium 90 (Y90) in patients with hepatocellular carcinoma (HCC) or metastatic colon cancer to the liver have been proven in several studies. However, f...

Radioembolization (RE), also termed selective internal radiation therapy (SIRT), has been gradually introduced to the clinical arsenal of cytoreductive modalities in recent years. There is growing evidence for efficiency in liver tumors of various entities, with the most prominent ones being hepatocellular carcinoma, colorectal cancer, and neuroendocrine tumors. Hepatic metastases of numerous o...

PURPOSE Intraarterial delivery of yttrium-90 ((90)Y)-bound microspheres (ie, radioembolization) is a promising treatment for hepatocellular carcinoma (HCC). An early concern was the "embolic" nature of the microspheres, and their potential to reduce hepatic arterial blood flow in patients with compromised portal blood flow secondary to portal vein thrombosis/occlusion (PVT). In this situation, ...

Introduction: Internal radiation therapy using radioactive Holmium-166 loaded microspheres (HoMS) has shown to be a promising technique for treatment of liver metastases [1]. Unlike Yttrium-90 microspheres, which lack imaging capabilities, HoMS can be detected by Single Photon Emission Computed Tomography (SPECT) using the Holmium-166 photopeak and by MRI using the paramagnetic properties of Ho...

TAKE-AWAY POINTS This multicenter international study randomized patients with metastatic colorectal cancer (mCRC) between first-line systemic chemotherapy alone and first-line systemic chemotherapy combined with yttrium-90 (Y-90) resin microspheres. Eligible patients with nonresectable liver-only or liver-dominant mCRC and no prior systemic chemotherapy were randomized 1:1 between both arms. T...

OBJECTIVE To discuss the basic concepts involved in the development of yttrium 90 (Y-90) microsphere selective internal radiation treatment and review the clinical data pertaining to its application in hepatic colorectal cancer metastases. DATA SOURCES Published studies and scientific paper presentations. STUDY SELECTION Randomized clinical studies and retrospective reviews. CONCLUSIONS S...

Abstract R&D program on HTGR fuel to support the RDE project has been outlined and is aimed develop national capabilities nuclear technology. The external sol-gel technology adopted for fabrication of kernels. Laboratory scale work ongoing at Center Nuclear Fuel Technology (PTBBN) BATAN study various parameters involved in process kernel including tuning related droplet formation (feed flow...