A combination of conformational search, energy minimization, and energetic evaluation using a continuum solvent treatment has been employed to study the stability of various conformations of the DNA fragment d(CGCAGAA)/d(TTCGCG) containing a single adenine bulge. The extra-helical (looped-out) bulge conformation derived from a published x-ray structure and intra-helical (stacked bulge base) mod...

There is much demand for the development of reliable methods of bulge site recognition in DNA in order to find disease-related mutations and identify bulge sequence environments. Herein, we found that the bulge site in the DNA duplex can be used to selectively grow fluorescent silver nanoclusters (Ag NCs). The as-prepared Ag NCs exhibit an emission behavior dependent on the base environment nea...

BACKGROUND Intact foveal bulge has been associated with good visual outcome in retinal diseases. The aim of this study was to study the variation in foveal bulge with age. METHODS It was an observational cross-sectional study conducted between October 2014 and December 2015. Totally, 101 eyes of 101 healthy volunteers were studied in a tertiary care center. All individuals had best corrected ...

Thirty-one RNA duplexes containing single-nucleotide bulge loops were optically melted in 1 M NaCl, and the thermodynamic parameters ΔH°, ΔS°, ΔG°(37), and T(M) for each sequence were determined. The bulge loops were of the group II variety, where the bulged nucleotide is identical to one of its nearest neighbors, leading to ambiguity as to the exact position of the bulge. The data were used to...

Demographic transitions in the Arab countries, due to declining birth rates and mortality rates since the 1980s, are reflected in a low proportion of children, a relatively stable proportion of elderly and a high proportion of people of working age. This "youth bulge" of young, active, working-age individuals in the current population may open a demographic window for countries to benefit from ...

Joel Cohen was asked by the conference organizers to focus a critical eye on demographic projections and to give special attention to the outlook for the elderly and for total dependency ratios. He was very faithful to his assignment. I have only a few points to raise about his paper before going on to discuss one issue that he did not cover (and was not asked to cover) but that I think should ...

The human hair follicle bulge is an important niche for keratinocyte stem cells (KSCs). Elucidation of human bulge cell biology could be facilitated by analysis of global gene expression profiles and identification of unique cell-surface markers. The lack of distinctive bulge morphology in human hair follicles has hampered studies of bulge cells and KSCs. In this study, we determined the distri...

Fluorine (F) abundances are derived in a sample of 6 bulge red giants in Baade’s Window. These giants span a factor of 10 in metallicity and this is the first study to define the behavior of F with metallicity in the bulge. The bulge results show an increase in F/O with increasing oxygen. This trend overlaps what is found in the disk at comparable metallicities, with the most oxygen-rich bulge ...

recently, offshore and ocean engineering have been dealing with novel materials that play a significant role in reducing the weight of structures used in the ship construction industry. 5xxx series of aluminum alloys are of the novel alloys are suitable for construction of ship hulls and the topside structures of offshore platforms. within different 5xxx aluminum alloys, aa5083 is of great impo...

background: the phylogenetic location of chinese spirometra sparganum isolates remains unclear. the aim of this study was to explore the phylogenetic location of the spirometra sparganum isolates from china. methods: the 28s ribosomal dna (rdna) d1 sequences of 14 spirometra sparganum isolates collected from thirteen locations in china were analyzed by using neighbor-joining (nj), maximum parsi...