OBJECTIVES The objective of this work is to evaluate the hemodynamic performance of a new Y-graft modification of the extracardiac conduit Fontan operation. The performance of the Y-graft design is compared to two designs used in current practice: a t-junction connection of the venae cavae and an offset between the inferior and superior venae cavae. METHODS The proposed design replaces the cu...

where y and y are the first and second derivatives of signal y(t). Given a known input x(t), we would like to integrate this differential equation to find an expression of y(t) that is only in terms of t. Then we can see how to adjust our design parameters so that y(t) has a desirable shape (e.g., even with a bumpy x(t) road surface, the car seat y(t) stays in one place). So we need a convenien...

Note Loss of the Y chromosome from individual metaphases is common in metaphase cells from both PHAstimulated lymphocytes and spontaneously dividing bone marrow cells. The frequency of Y loss is greater in older men, and the size of the 45,X,-Y cell population probably increases gradually with advancing age. (In females, a corollary loss of one X chromosome also occurs with advancing age.) This...

Setup Given a Markov chain and pre-metric on Ω, our goal is to design a good coupling. Recall that a pre-metric on Ω is a weighted graph (Ω, Epre) in which every edge is a shortest path, and we name the induced shortest path metric d. In the previous lecture we proved the Path Coupling Theorem: Theorem 1 (Path Coupling). Suppose we have a coupling for all (x, y) ∈ Epre and suppose that there ex...

In artificial gravity, conformance to the hypothetical comfort zone does not guarantee an earth-normal environment, nor does it sanction design based on terrestrial norms. This paper begins by examining the range of gravity environments encompassed by the comfort zone. It compares Coriolis slope distortions with typical slopes in terrestrial architecture. It then offers a detailed analysis of t...

This paper introduces the simple cell mapping (SCM) method for the multi-objective optimal time domain design of feedback controls for linear systems with or without time delay. The SCM method is originally developed for the global analysis of nonlinear dynamical systems, and is extended to the multi-objective optimal design problem of feedback controls in this paper. We consider two feedback c...

This paper presents parallel signature design techniques that guarantee the aliasing probability to be less than 2/L, where L is the test length. Using y signature samples, a parallel signature analysis design is proposed that guarantees the aliasing probability to be less than (y/L). Inaccuracies and incompleteness in previously published bounds on the aliasing probability are discussed. Simpl...

A quasi-symmetric design (QSD) is a (v, k, λ) design with two intersection numbers x, y, where 0 ≤ x < y < k. The block graph of a QSD is a strongly regular graph (SRG), whereas the converse is not true. Using Neumaier’s classification of SRGs related to the smallest eigenvalue, a complete parametric classification of QSDs whose block graph is an SRG with smallest eigenvalue −3, or second large...