Wound healing proceeds in a By Cornelius M. Donohue, DPM, Larry R. Goss, DPM, Frederick B. LaVan, MD, Michael S. Weingarten, MD, and Mazen A. Abboud, DPM Objectives 1) Review the stage of wound healing, including the major molecular and cellular events. 2) Review the classification and common causes of lower extremity wounds as well as factors affecting wound healing. 3) Introduce a ten-step cl...

OBJECTIVE Successful closure is a primary step of treatment in open fracture wounds. Delayed healing or complications can lead to increased treatment duration, costs and disability rates. The aim of this study was to compare Negative Pressure Wound Therapy (NPWT) and conventional wound dressings in patients with open fracture wounds. METHODS In a prospective randomized clinical trial study, 9...

introduction: acute skin wound healing is a complicated process comprising various phases. recent animal studies have shown that steroid sex hormones such as estrogen maybe helpful in the regulation of several pathophysiologic stages that are involved in wound healing. in this study we examined the effects of topical estrogen in the treatment of traumatic facial wounds.   materials and methods:...

Diabetes mellitus is associated with chronic diabetic foot ulcers (DFUs) and wound infections often resulting in lower extremity amputations. The protein signaling architecture of the mechanisms responsible for impaired DFU healing has not been characterized. In this preliminary clinical study, the intracellular levels of proteins involved in signal transduction networks relevant to wound heali...

The diagnosis and management of peripheral vascular disease has undergone tremendous change during the past two decades. Diagnostic angiography is complemented and, in some cases, even supplanted by digital subtraction techniques, duplex sonography, intravascular ultrasound, and magnetic resonance imaging. Similarly, percutaneous transluminal angioplasty has evolved from a novelty to a vital co...

Abstract Background Peripheral artery disease (PAD) is a major challenge worldwide and endovascular revascularization an important component of treatment that affected by COVID-19 restrictions. Purpose Here, we evaluated the impact restriction on angioplasty service outcome patients undergoing lower limb angioplasty. Methods Consecutive revascularisation between August 2018-March 2021 in UK dis...

Diabetic foot infections are a high risk for lower extremity amputation in patients with dense peripheral neuropathy and/or peripheral vascular disease. When they present with concomitant osteomyelitis, it poses a great challenge to the surgical and medical teams with continuing debates regarding the treatment strategy. A cohort prospective study conducted between October 2005 and October 2010 ...

UNLABELLED Lower-extremity ulcers represent the largest group of ulcers presenting to an outpatient wound care clinic and, of those, ulcers due to venous insufficiency and venous hypertension make up the largest subgroup of these ulcers. Interventions for chronic venous ulcers have evolved to painless, minimally invasive, office-based procedures performed under local anesthesia. Recent advances...