Abstract Background Supplementation with exclusive enteral nutrition (EEN) in addition to standard of care intravenous corticosteroids (SOC) augments the steroid response patients acute severe ulcerative colitis (ASUC). EEN is known alter gut microbial composition. The present study identifies changes microbiota driven by ASUC receiving therapy and examines correlations between EEN-associated b...

The enteric nervous system (ENS) derives from neural crest, which invade and migrate along the developing gut, proliferate extensively, and differentiate into neurons and glial cells organized as interconnected ganglia that control complex behaviours of the gut, such as peristalsis. While most ENS progenitors undergo differentiation, cells exhibiting properties of enteric progenitor cells (EPCs...

A common feature of early vertebrate embryos is that they are surrounded by a simple protective epithelial cell layer. However, it is currently not well understood how the differentiation of this epithelium is controlled. We present data showing that BMP4 is sufficient to promote differentiation of this epithelium in diverse vertebrates. In mouse embryos the outer epithelium forms the trophecto...

Nuage, a well conserved perinuclear organelle found in germline cells, is thought to mediate the repression of retroelements in Drosophila melanogaster by regulating the production of Piwiinteracting RNAs (piRNAs). Here, we present evidence that the nuage/piRNA pathway components can be found in cytoplasmic foci that also contain retroelement transcripts, anti-sense piRNAs and proteins involved...

07-P001 Differential hind leg development in Apis mellifera castes Ana Durvalina Bomtorin, Livia Moda, Marcela A.F.B. Laure, Alexandre S. Cristino, Michelle P.M. Soares, Rodrigo A. Faccioli, Marcia M.G. Bitondi, Angel Roberto Barchuk, Zila L.P. Simoes Departamento de Genetica-FMRP/USP, Ribeirao Preto, Sao Paulo, Brazil Departamento de Fsica e Informtica – IFSC/USP, Sao Carlos, Sao Paulo, Brazil...

Vertebrate neurotrophins (NTs: NGF, BDNF, NT3, NT4) form a family of signalling molecules with key functions in nervous system development and function. They regulate cell survival, axon guidance and targeting, synaptic formation and function, learning and memory. Deficient NGF function occurs in Alzheimer’s disease and alterations in BDNF function underlie psychiatric and cognitive disorders s...