Accumulating evidence suggest that nonhuman organisms, including invertebrates, possess the ability to make non-random choices based purely on ongoing and endogenously-created neuronal processes. We study this precursor of spontaneity in cockroaches stung by A. compressa, a parasitoid wasp that employs cockroaches as a live food supply for its offspring. This wasp uses a neurotoxic venom cockta...

Background. The Allergy Lateral Flow Assay (ALFA) is a novel rapid assay for the detection of sIgE to allergens. The objective of this study is the evaluation of ALFA for the detection of sIgE to bee venom (BV) and wasp venom (WV) in insect venom allergic patients. Methods. Specific IgE to BV and WV was analyzed by ALFA, ALLERG-O-LIQ, and ImmunoCAP in 80 insect venom allergic patients and 60 co...

Introduction: Insect venom allergy (IVA) is related to a higher risk of life-threatening anaphylactic reactions, resulting in decreased quality of life (QoL). Aim: The aim of the study is to: (1) assess the QoL, anxiety and depression among patients treated with venom immunotherapy (VIT) and influence of VIT on the QoL, (2) compare patients with improvement and deterioration in VQLQ during VIT ...

BACKGROUND Each year in the UK, there are between two and nine deaths from anaphylaxis caused by bee and wasp venom. Anaphylactic reactions can occur rapidly following a sting and can progress to a life-threatening condition within minutes. To avoid further reactions in people with a history of anaphylaxis to bee and wasp venom, the use of desensitisation, through a process known as venom immun...

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Allergen immunotherapy presents an opportunity to define mechanisms of induction of clinical tolerance in humans. Significant progress has been made in our understanding of changes in T cell responses during immunotherapy, but existing work has largely been based on functional T cell assays. HLA-peptide-tetrameric complexes allow the tracking of antigen-specific T-cell populations based on the ...

Predators as diverse as snakes, scorpions, spiders, insects and snails manufacture venoms to incapacitate their prey. Most venoms contain a cocktail of neurotoxins and each neurotoxin is designed to target specific receptors in the nervous and muscular systems. Most neurotoxins act peripherally and interfere with the ability of the prey's nervous system to generate muscle contraction or relaxat...