Aim: Warfarin has a narrow therapeutic index. We aimed to evaluate the effect of frailty on compliance warfarin pharmacotherapy and attainment international normalised ratio (INR) goals in patients aged over 65 years receiving warfarin.
 
 Method: recruited 473 elderly subjects over. Indications for administration INR values were recorded. All assessed according Clinical Frailty Scale...

BACKGROUND The polymorphisms of VKORC1 and CYP2C9 play increasingly important roles in the inter-individual variability in warfarin dose. This study aimed to evaluate the feasibility of clinical application of pharmacogenetic-based warfarin-dosing algorithm in patients of Han nationality with rheumatic heart disease after valve replacement in a randomized and controlled trial. METHODS One hun...

An examination of the metabolic fate of the R and the S isomers of warfarin revealed that the two isomers were metabolized by different routes. R warfarin was oxidized to 6-hydroxywarfarin and was reduced to the (R,S) warfarin alcohol. In contrast, S warfarin was oxidized to 7-hydroxywarfarin and was reduced to the (S,S) warfarin alcohol. S warfarin was also oxidized to 6-hydroxywarfarin. These...

BACKGROUND Warfarin is an anticoagulant with a narrow therapeutic index that is involved in a number of drug-drug interactions. OBJECTIVES This study evaluates the potential effect of odanacatib (a cathepsin K inhibitor in development for the treatment of osteoporosis) on the pharmacokinetics and pharmacodynamics of warfarin. METHODS In a randomized, open-label, two-period fixed-sequence de...

Wild roof rats (Rattus rattus) live in proximity to human habitats, and they may carry numerous pathogens of infectious diseases. Pest control is important for public health, and warfarin is a commonly used rodenticide worldwide. However, continual use of warfarin may cause drug resistance in rodents and lead to failure of their control, especially in urbanized areas. In warfarin-resistant rats...

Iguratimod is a novel disease-modifying antirheumatic drug. A blue letter (safety advisory) for drug interaction between iguratimod and warfarin was issued by the Ministry of Health, Labour and Welfare of Japan in May 2013. Iguratimod may affect warfarin metabolism catalyzed by CYP. However, it is not clear whether iguratimod inhibits warfarin oxidation. This study was performed to investigate ...

INTRODUCTION The pharmacokinetic/pharmacodynamic effects of warfarin were assessed in the presence and absence of taranabant, an orally active, highly selective, potent, cannabinoid-1 receptor inverse agonist, which was being developed for the treatment of obesity. METHODS Twelve subjects were assigned to two open-label treatments in fixed sequence separated by a 14-day washout. Treatment A w...

To evaluate the effectiveness of an anticoagulation protocol adapted in a mobile application (appG) for patients using warfarin. This was cluster randomized controlled clinical trial carried out basic health centers Ijui, RS, Brazil, between April and October 2017. The appG installed on cell phones all physicians belonging to intervention group. Primary outcomes were bleeding thrombosis, second...

Article history: Received on: 01/06/2016 Revised on: 18/08/2016 Accepted on: 05/09/2016 Available online: 29/11/2016 This study was conducted to evaluate the changes in warfarin doses among patients after heart valve surgery and atrial fibrillation. A total of 137 patients having AF, AVR and MVR whom initiate warfarin therapy in year 2008 till 2010 in Penang Hospital were selected as samples fo...

conclusions simpleprobe® real-time pcr is a fast and accurate technique qualified to detect vkorc1 and cyp2c9 snps. these results encourage taking further steps towards using vkorc1 and cyp2c9 allelic screening to prevent clinical complications due to resistance or sensitivity to warfarin as well as anti-coagulant dose adjustment. results the allelic frequencies for vkorc1 c1173t (cc, ct, tt) w...