نتایج جستجو برای: vsvg protein

تعداد نتایج: 1234696  

2008
Suliana Manley Jennifer M Gillette George H Patterson Hari Shroff Harald F Hess Eric Betzig Jennifer Lippincott-Schwartz

We combined photoactivated localization microscopy (PALM) with live-cell single-particle tracking to create a new method termed sptPALM. We created spatially resolved maps of single-molecule motions by imaging the membrane proteins Gag and VSVG, and obtained several orders of magnitude more trajectories per cell than traditional single-particle tracking enables. By probing distinct subsets of m...

2015
Monica Giannotta Giorgia Fragassi Antonio Tamburro Capone Vanessa Alberto Luini Michele Sallese

The KDEL receptor (KDELR) is a seven-transmembrane-domain protein involved in retrograde transport of protein chaperones from the Golgi complex to the endoplasmic reticulum. Our recent findings have shown that the Golgi-localised KDELR acts as a functional G-protein-coupled receptor by binding to and activating Gs and Gq. These G proteins induce activation of PKA and Src and regulate retrograde...

2011
Mona Johannessen Mari Walquist Nancy Gerits Marte Dragset Anne Spang Ugo Moens

BACKGROUND The human polyomavirus BK (BKV) infects humans worldwide and establishes a persistent infection in the kidney. The BK virus genome encodes three regulatory proteins, large and small tumor-antigen and the agnoprotein, as well as the capsid proteins VP1 to VP3. Agnoprotein is conserved among BKV, JC virus (JCV) and SV40, and agnoprotein-deficient mutants reveal reduced viral propagatio...

Journal: :The Biochemical journal 2011
Liron Yosha Orly Ravid Nathalie Ben-Califa Drorit Neumann

Lysine residues are key residues in many cellular processes, in part due to their ability to accept a wide variety of post-translational modifications. In the present study, we identify the EPO-R [EPO (erythropoietin) receptor] cytosolic lysine residues as enhancers of receptor function. EPO-R drives survival, proliferation and differentiation of erythroid progenitor cells via binding of its li...

Journal: :Journal of cell science 2008
Selma Y Dejgaard Ayesha Murshid Aysegül Erman Ozge Kizilay David Verbich Robert Lodge Kurt Dejgaard Thi Bach Nga Ly-Hartig Rainer Pepperkok Jeremy C Simpson John F Presley

Rabs and Arfs/Arls are Ras-related small GTPases of particular relevance to membrane trafficking. It is thought that these proteins regulate specific pathways through interactions with coat, motor, tether and SNARE proteins. We screened a comprehensive list of Arf/Arl/Rab proteins, previously identified on purified Golgi membranes by a proteomics approach (37 in total), for Golgi or intra-Golgi...

Journal: :The Biochemical journal 2012
Maaike Kockx Donna L Dinnes Kuan-Yen Huang Laura J Sharpe Wendy Jessup Andrew J Brown Leonard Kritharides

Cholesterol excess is typical of various diseases including atherosclerosis. We have investigated whether cholesterol accumulation in the ER (endoplasmic reticulum) can inhibit exit of vesicular cargo and secretion of proteins by studying apoE (apolipoprotein E), a significant glycoprotein in human health and disease. CHO (Chinese hamster ovary) cells expressing human apoE under a cholesterol-i...

2011
Marimuthu Subathra Asfia Qureshi Chiara Luberto

Sphingomyelin synthases (SMS1 and 2) represent a class of enzymes that transfer a phosphocholine moiety from phosphatidylcholine onto ceramide thus producing sphingomyelin and diacylglycerol (DAG). SMS1 localizes at the Golgi while SMS2 localizes both at the Golgi and the plasma membrane. Previous studies from our laboratory showed that modulation of SMS1 and, to a lesser extent, of SMS2 affect...

Journal: :The Journal of Cell Biology 2008
Rita L. Nokes Ian C. Fields Ruth N. Collins Heike Fölsch

To maintain polarity, epithelial cells continuously sort transmembrane proteins to the apical or basolateral membrane domains during biosynthetic delivery or after internalization. During biosynthetic delivery, some cargo proteins move from the trans-Golgi network (TGN) into recycling endosomes (RE) before being delivered to the plasma membrane. However, proteins that regulate this transport st...

2011
Maritza Calame Maité Cachafeiro Stéphanie Philippe Karine Schouwey Meriem Tekaya Dana Wanner Chamsy Sarkis Corinne Kostic Yvan Arsenijevic

In normal mice, the lentiviral vector (LV) is very efficient to target the RPE cells, but transduces retinal neurons well only during development. In the present study, the tropism of LV has been investigated in the degenerating retina of mice, knowing that the retina structure changes during degeneration. We postulated that the viral transduction would be increased by the alteration of the out...

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