OBJECTIVES No comparison of balloon- or self-expandable valved stents (VSs) regarding tissue injury (if any) has been reported yet. The objective was to evaluate the occurrence and compare the severity of traumatic injury to leaflets from balloon- or self-expandable VSs. METHODS Twelve homemade VSs were used for this experiment. These three-leaflet bovine pericardial bioprostheses had either ...

Introduction: Spectroscopic imaging based on conventional 3D PRESS localization is improved by using very selective suppression (VSS) pulses for outer volume suppression [1]. Cosine-modulated VSS pulses can be used to simultaneously suppress two parallel bands [2] but doubles the required peak RF amplitude. This abstract presents an efficient method for designing a dualband VSS pulse that requi...

The aim of the present study was to determine whether Cremophor EL is a suitable surfactant that can be routinely applied to pharmacokinetic (PK) studies in early drug discovery without influencing the intrinsic PK characteristics of the new chemical entities (NCEs). Cremophor EL, a polyoxyl 35 castor oil, has been used as a solubilization aid for water-insoluble compounds in pre-clinical drug ...

The round complexity of interactive protocols is one of their most important complexity measures. In this work we prove that existing lower bounds for the round complexity of VSS can be circumvented by introducing a negligible probability of error in the reconstruction phase. Previous results show matching lower and upper bounds of three rounds for VSS, with n = 3t + 1, where the reconstruction...

Verifiable secret sharing (VSS) is a fundamental cryptographic primitive, lying at the core of secure multi-party computation (MPC) and, as the distributed analogue of a commitment functionality, used in numerous applications. In this paper we focus on unconditionally secure VSS protocols with honest majority. In this setting it is typically assumed that parties are connected pairwise by authen...

Replacement of hydrogenwith fluorine within three pairs of structurally similar small molecule inhibitors of heat shock protein 90 (HSP90) resulted in differences in inhibition constants (Ki) in vitro as well as marked differences in rat intravenous pharmacokinetic profiles. The difference in pharmacokinetic profiles between lower and higher affinity inhibitors (LAIs and HAIs, respectively) was...

We consider the round complexity of a basic cryptographic task: verifiable secret sharing (VSS). This well-studied primitive provides a good “test case” for our understanding of round complexity in general; moreover, VSS is important in its own right as a central building block for, e.g., Byzantine agreement and secure multi-party computation. The round complexity of perfect VSS was settled by ...

The pharmacokinetics of N-nitrosodimethylamine was studied in patas monkeys following i.v. doses of 0.5, 1.0, and 5.0 mg/kg and a p.o. dose of 1.0 mg/kg, and in Swiss mice at i.v. doses of 1.0 and 2.0 mg/kg. In the patas monkey the pharmacokinetics was linear over the i.v. dose range studied. The mean clearance (Cl), steady-state volume of distribution (Vss), mean residence time, and eliminatio...