The aim of the study was to investigate the possibility of improving the therapeutic efficacy of the total alkaloid fraction (TAF) extracted from processed nux vomica by reducing the strychnine contents. Most strychnine was removed from TAF to obtain the modified total alkaloid fraction (MTAF). The toxicity and pharmacokinetics of TAF and MTAF were further investigated and compared besides thei...

Introduction - Medicinal plants, as well poisonous have different alkaloid compositions in every season. According to the traditional texts of Ayurveda, Visha Dravya greater potency Varsha Ritu, which reduces due Agasti rising Sharad Ritu. Objective To evaluate and Ritu through estimation concentration Strychnine Strychnos nux- vomica L. Materials Methods – Quantitative analysis by HPTLC. Resul...

A capillary zone electrophoresis (CZE) method has been developed for investigating the physicochemical characteristics of five Strychnos alkaloids in Strychnos nux-vomica L. Firstly, the dissociation constants of the five Strychnos alkaloids were determined, based on the relation between the effective mobility of the solutes and the buffer pH. The mathematical relationship was strictly deduced ...

conclusions clinically, these results are logical because the required dose of alkaloids for treatment of diarrhea is lesser than the needed doses to treat addiction, arthralgia, and paralysis. results the first itm method reduced the strychnine level from 1.083 to 0.577 and brucine from 0.739 to 0.361. for the second and third itm methods, the levels of strychnine reached 0.838 and 0.812, and ...

Traditional Chinese medicine has been used to treat disease in China for more than five thousand years. Over the last few decades it has been used increasingly in other countries as well. As its use has spread, interest in the adverse effects of traditional Chinese medicine, including epilepsy and epileptic seizures, has grown. To date, four types of traditional Chinese medicine have been found...