A comparison of the effect of isothiocyanates and nitriles derived from some glucosinolates, namely, epi-progoitrin, sinalbin, glucotropaeolin, glucocheirolin, and glucoraphenin, on human erythroleukemic in vitro cultured cells was studied. Many studies have in fact evidenced that a consumption of vegetable containing glucosinolates could reduce the development of colorectal cancer. In the expe...

Isothiocyanates and their naturally occurring glucosinolate precursors are widely consumed as part of a diet rich in cruciferous vegetables. When plant cells are damaged, glucosinolates are released and converted to isothiocyanates by the enzyme myrosinase. Many isothiocyanates inhibit the neoplastic effects of various carcinogens at a number of organ sites. Consequently, these agents are attra...

The isothiocyanates present in the cruciferous plants were proved to have the antiproliferative and cytotoxic effect on cancer cell lines. Natural compounds in combination with chemotherapy agents enhance anticancer activities of drugs and reduce their toxicity. The aim of the presented study was to determine an effect of isothiocyanates and 5-fluorouracil used alone or in combination (in seque...

Vegetables of the Brassica oleracea group, such as broccoli, cauliflower, and cabbage, play an important role for glucosinolate consumption in the human diet. Upon maceration of the vegetable tissue, glucosinolates are degraded enzymatically to form volatile isothiocyanates, nitriles, and epithionitriles. However, only the uptake of isothiocyanates is linked to the cancer-preventive effects. Th...

antifungal and antibacterial activities at concentrations of 7.8 to 15,6uglml, respectively, and that a possible target of the ITC compounds might be the cellular sulfhydryl group, In recent years, a number of multidrug transporters have been found in various organisms including bacteria and human cells.3) A promising way to conquer such multidrug resistance is to inactivate the eMux protein in...

Carbon-substituted isocyanates and isothiocyanates are common building blocks in organic synthesis. In contrast, synthetic uses of N-substituted isocyanates and isothiocyanates are severely underdeveloped: few have been reported and their reactivity had not been compared. Herein, we compare the reactivity of blocked (masked) N-isocyanate and N-isothiocyanate precursors in cascade reactions. Div...

An efficient synthesis of 1,3-thiazole drivatives is described via a three component reaction isothiocyanates, tetramethyl thiourea and ethyl bromopyruvate.

A one-pot, tandem process has been developed for the synthesis of a library of tetrazoles from aryl isothiocyanates. Condensation of aryl isothiocyanates with ammonia, and aryl amines (R-NH(2)) provided mono, 1,3-disubstituted symmetrical and unsymmetrical thioureas, which on desulfurization with molecular iodine (I(2)) led to formation of the corresponding heterocumulene (cyanamides or carbodi...

This paper deals with the synthesis of three up to date not described 4-(£>-terphenylyl)isothiocyanates and their six intermediates, two of which having not been described, too. A procedure was developed to identify £>-terphenyl derivatives by means of thin layer chromatography on alumina, as well as by gas chromatography. Infra-red and ultra-violet spectra were taken of the synthetized 4-(30-t...