Event-related potential (ERP) approaches to social cognitive and affective neuroscience (SCAN) are not as widely used as other neuroimaging techniques, yet they offer several unique advantages. In particular, the high temporal resolution of ERP measures of neural activity make them ideally suited for studying the dynamic interplay of rapidly unfolding cognitive and affective processes. In this ...

The terminal differentiation of hypertrophic chondrocytes is a tightly regulated process that plays a pivotal role in endochondral ossification. As a negative regulator, Sox9 is essentially downregulated in terminally differentiated hypertrophic chondrocytes. However, the underlying mechanism of Sox9 silencing is undefined. Here we show that the zinc finger protein Zbtb20 regulates the terminal...

OBJECTIVE This study investigated the relationship between cardiorespiratory fitness (CRF) and adiposity in young adults. METHODS Data was collected from 133 students of a medical college of Pakistan. The study was conducted on young adults, aged 17-24 years, recruited from Jinnah Medical & Dental College, Karachi, between Aug-Dec, 2015. Queen's College Step Test was conducted to measure CRF ...

Cardiorespiratory fitness [maximal O2 consumption (VO2max)] is an independent risk factor for type 2 diabetes; but in individuals at risk, factors influencing VO2max are poorly understood. We tested the hypothesis that VO2max is associated with diastolic function [subendocardial variability ratio (SEVR), %], as diastolic function influences myocardial perfusion. We studied 47 men and women with...

Several lines of evidence indicate that the sarco(endo)plasmic reticulum ATPase type 2 (SERCA2) is essential for maintaining myocardial calcium handling and cardiac pump function. Hence, a reduction in SERCA2 abundance is expected to reduce work performance and maximal oxygen uptake (VO2max) and to limit the response to exercise training. To test this hypothesis, we compared VO2max and exercise...

Objective To evaluate how rating of perceived capacity (RPC) is related to maximal oxygen uptake (VO2max) and examine VO2max at onset of training in healthy adults. Methods In total, 125 newly registered fitness centre members, equally men and women, answered the RPC scale and performed a treadmill test for measurement of VO2max. Eligible criteria were <4 weeks of fitness centre membership, p...

BACKGROUND The purpose was to develop new maximal oxygen uptake (VO2max) prediction models using a perceptually regulated 3-minute walk test. METHODS VO2max was measured with a maximal incremental cycle test in 283 Japanese adults. A 3-minute walk test was conducted at a self-regulated intensity corresponding to ratings of perceived exertion (RPE) 13. RESULTS A 3-minute walk distance (3MWD)...

PURPOSE The purpose of this study was to compare VO2max, VO2-time slopes at the end of the protocol (last 30 s), and the presence of a VO2 plateau (VO2-time slope < 0.05 L.min(-1) during the last 30 s) across four protocol durations (5, 8, 12, and 16 min) during incremental cycling exercise to VO2max. METHODS Eight male (23.8 +/- 3.2 yr) and eight female (26.0 +/- 8.9 yr) subjects of moderate...