Abstract: Introduction: Formulation of a nano lipid carrier loaded hydrophilic gel corticosteroid, fluticasone propionate (FP) was investigated systemically with response surface model (RSM) for promising dermal delivery the drug. Objectives: To achieve better penetration drug and to overcome generally associated adverse reactions corticosteroids, present study, explored formulation evaluation ...

Purpose To determine in vitro release profiles, transcorneal permeation, and ocular injection characteristics of a voriconazole-containing thermogel suitable for injection into the subconjunctival space (SCS). Methods In vitro release rate of voriconazole (0.3% and 1.5%) from poly (DL-lactide-co-glycolide-b-ethylene glycol-b-DL-lactide-co-glycolide) (PLGA-PEG-PLGA) thermogel was determined fo...

Transdermal patches were developed for a low oral bioavailable drug, lacidipine (LCDP) employing ethyl cellulose/Eudragit RL100 and polyvinyl pyrollidone (PVP) as polymeric matrices. The effect of binary mixtures of polymers on physicochemical properties such as thickness, moisture absorption and moisture content; in vitro release, ex vivo permeation and mechanical properties was evaluated. Ex ...

The gastric irritant effects of peroral lornoxicam can be attenuated using skin as the route of administration. The present work was focused on the development, characterization, ex vivo skin permeation and skin targeting behaviors of lornoxicam-loaded solid lipid nanoparticles (SLN). Lornoxicam loaded SLN was prepared by emulsification solvent evaporation technique. The particle size and polyd...

This study aimed to comprehensively assess the transcorneal permeation, antimicrobial, and antifungal activities of a nanosuspension loaded with Andrographolide, promising herbal compound. Through combination in vitro vivo studies, efficacy, potential applications ocular drug delivery were investigated. In phase, permeation studies conducted using Franz diffusion cells excised rabbit corneas. T...

We have found that an enzyme-modified cheese (EMC) inhibited the permeation of allergens such as ovalbumin (OVA), using Caco-2 cells as an in vitro intestinal epithelial model. In addition, NPWDQ (Asn-Pro-Trp-Asp-Gln, aa 107-111 of alphas(2)-casein) was isolated from EMC and identified as one of the responsible peptides for this inhibitory activity (Tanabe et al., J. Agric. Food Chem., (2007))....

The aim of present study were to arrest the problem of content uniformity without the use of harmful organic solvent and to improve ex vivo permeability of captopril, a low dose class III drug as per biological classification system. Eutectic mixture of camphor and menthol was innovatively used in the work. Captopril solution in eutectic mixture was blended with Avicel PH 102 and then the mixtu...

BACKGROUND AND THE PURPOSE OF THE STUDY Domperidone (DOM) is a dopamine- receptor (D(2)) antagonist, which is widely used in the treatment of motion-sickness. The pharmacokinetic parameters make DOM a suitable candidate for transdermal delivery. The purpose of the present investigation was to develop transdermal delivery systems for DOM and to evaluate their physicochemical characteristics, in ...

CONTEXT Buspirone HCl has very low oral bioavailability (4%) due to deactivation by extensive first pass effect. It also has very limited transdermal permeation due to its high hydrophilicity. OBJECTIVE The aim of this study was to increase the transdermal permeation of buspirone HCl utilizing a stable dosage form. METHODS Transfersomes were prepared using Tween-80 as a flexibility impartin...

The aim of the present study was to investigate transfersomes as a transdermal delivery system for the poorly soluble drug, sertraline, in order to overcome the troubles associated with its oral delivery. Different transfersomal formulations were prepared with non-ionic surfactant (span 80), soya lecithin, and carbopol 940 by the rotary evaporation sonication method. The prepared formulations w...